Neural regulation of inflammatory kidney diseases

• Project/Area Number: 16H06751
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Nishi Hiroshi 東京大学, 医学部附属病院, 助教 (90784174)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 腎臓 / 腎 / 神経 / 炎症 / 白血球

Outline of Final Research Achievements

Several neural network related molecules were discovered through a high throughput screen of small molecules to identify a drug which can inactivate neutrophil Fc γ receptor activation signals. Inflamed end tissues and organs due to neutrophil activation were partly attenuated by administration of these chemicals to animals. Immunohistochemical analysis revealed peripheral innervation in the kidney interstitial area. The tissue injury of neutrophil mediated diseases was altered in the neural peptide precursor deficient animals.

Research Products

• [Journal Article] Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases (2017)
  • Author(s): Hiroshi Nishi, Kazuhiro Furuhashi, Xavier Cullere, Gurpanna Saggu, Mark Miller, Yunfeng Chen, Florencia Rosetti, Samantha Hamilton, Lihua Yang, Spencer Pittman, Jiexi Liao, Jan Herter, Jeffrey Berry, Daniel DeAngelo, Cheng Zhu, George Tsokos, Tanya Mayadas
  • Journal Title: Journal of Clinical Investigation Volume: 127 Issue: 10 Pages: 3810-3826
  • DOI: 10.1172/jci94039
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lupus and proliferative nephritis are PAD4 independent in murine models (2017)
  • Author(s): Rachael Gordon, Jan Herter, Florencia Rosetti, Allison Campbell, Hiroshi Nishi, Michael Kashgarian, Sheldon Bastacky, Anthony Marinov, Kevin Nickerson, Tanya Mayadas, Mark Jay Shlomchik
  • Journal Title: JCI insight Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PKC-δ activation in neutrophils promotes fungal clearance (2016)
  • Author(s): Xun Li, Xavier Cullere, Hiroshi Nishi, Gurpanna Saggu, Enrique Durand, Michael Mansour, Jenny Tam, Xiu-yu Song, Xin Lin, Jatin Vyas, Tanya Mayadas
  • Journal Title: J Leukoc Biol Volume: 100 Issue: 3 Pages: 581-588
  • DOI: 10.1189/jlb.4a0915-405r
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation. (2016)
  • Author(s): Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, Mayadas T, Hirohama D, Suzuki K, Kawakami H, Tanaka M, Kurosawa M, Kagaya S, Hishikawa K, Nangaku M, Fujita T, Hayashi M, Hirahashi J.
  • Journal Title: EBioMedicine Volume: 10 Pages: 204-215
  • DOI: 10.1016/j.ebiom.2016.07.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] FcγRIIA-driven glomerular neutrophil accumulation and proliferative glomerulonephritis are averted with inhibiton of neutrophil Bcr-Abl kinases. (2018)
  • Author(s): Hiroshi Nishi, Kazuhiro Furuhashi, Xavier Cullere, Gurpanna Saggu, Mark Miller, Yunfeng Chen, Florencia Rosetti, Samantha Hamilton, Lihua Yang, Spencer Pittman, Jiexi Liao, Jan Herter, Jeffrey Berry, Cheng Zhu, George C. Tsokos, Tanya Mayadas
  • Organizer: ISN Frontiers Meetings 2018 on Kidney Disease & Cardiovascular Disease.
• [Presentation] Neutrophil interferon-induced, double-stranded RNA-activated protein kinase regulates stimulation-induced migration and production of reactive oxygen species. (2018)
  • Author(s): Reiko Inoue, Hiroshi Nishi, Masaomi Nangaku
  • Organizer: ISN Frontiers Meetings 2018 on Kidney Disease & Cardiovascular Disease.
• [Presentation] Culture of low concentration of oxygen amplifies slow twitch muscle fiber gene expression in skeletal C2C12 myotubes. (2018)
  • Author(s): Koji Takemura, Hiroshi Nishi, Masaomi Nangaku
  • Organizer: ISN Frontiers Meetings 2018 on Kidney Disease & Cardiovascular Disease.
• [Presentation] 赤血球・白血球から捉えた腎臓病のリサーチ． (2017)
  • Author(s): 西裕志
  • Organizer: 第5回Tokyo Kidney Conference
  • Invited
• [Presentation] Hypoxic stimuli and hemoglobin effect on skeletal muscle (2017)
  • Author(s): 西裕志
  • Organizer: 一般社団法人日本アンチ・ドーピング研究コンソーシアムシンポジウム2017
  • Invited
• [Presentation] 腎糸球体毛細血管で観る好中球の挙動と創薬応用 (2017)
  • Author(s): 西裕志
  • Organizer: 第70回Blood Vessel Club
  • Invited
• [Presentation] 行政の立場から見たチーム医療 (2017)
  • Author(s): 佐々木昌弘，福井亮，西裕志
  • Organizer: 第11回日本CKDチーム医療研究会
  • Invited
• [Presentation] 低分子化合物スクリーニングが明らかにしたループス腎炎における免疫複合体と好中球 Abl kinase の役割 (2016)
  • Author(s): 西裕志
  • Organizer: 第2回川島カンファレンス
  • Place of Presentation: 岐阜
  • Year and Date: 2016-10-23
  • Invited
• [Book] 腎と透析 (2018)
  • Author(s): 井上玲子，西裕志，南学正臣
  • Publisher: 東京医学社