A new murine model of SSc/SLE overlap syndrome
Project/Area Number |
16H06754
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Collagenous pathology/Allergology
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Research Institution | The University of Tokyo |
Principal Investigator |
Akamata Kaname 東京大学, 医学部附属病院, 助教 (00779788)
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Project Period (FY) |
2016-08-26 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 全身性強皮症 / 全身性エリテマトーデス / 動物モデル / Fli1 / KLF5 / 病態干渉 / 重複症候群 / TLR7 / TLR |
Outline of Final Research Achievements |
Systemic sclerosis (SSc)/ systemic lupus erythematosus (SLE) overlapy syndrome is characterized by the low frequency of lupus nephritis and the high frequency of serositis, but the molecular mechanism underlying this observation has still remianed unknown. To investigate the molecular mechanism regulating the pathological interference between SSc and SLE, we decided to generate a new overlapy syndrome animal model, namely, Klf5+/-;Fli1+/- mice treated with imiquimod, in which double heterozygous loss of KLF5 and Fli1 induces SSc symptoms and imiquimod administration induces lupus symptoms. At the time of writing, we have demonstrated that Klf5+/-;Fli1+/- mice develop cardiac and intestinal symptoms similar to those of SSc without renal invovlement. Now, we are investigating whether imiquimod-induced lupus symptoms are modified in Klf5+/-;Fli1+/- mice. The histological analysis of the skin, lung, heart, kidney, esophagus, and intestine is now on going.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.2017
Author(s)
Takehiro Takahashi, Yoshihide Asano, Koji Sugawara, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Kaname Akamata, Shinji Noda, Ayumi Yoshizaki, Daisuke Tsuruta, Maria Trojanowska, and Shinichi Sato
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Journal Title
Journal of Experimental Medicine
Volume: 214
Issue: 4
Pages: 1129-1151
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant