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Analysis of cell cycle related signals for inhibition of histone acetylation in pancreatic cancer cells

Research Project

Project/Area Number 16H06773
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ONO Hiroaki  東京医科歯科大学, 医学部附属病院, 助教 (60466901)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords膵臓癌 / 細胞周期 / 抗がん剤 / 腫瘍外科 / 分子細胞学
Outline of Final Research Achievements

Histone Acetylation plays a significant role in DNA replication and regulation of cell cycle. We tried to investigate its relationship between Histone acetylation and cell cycle especially in pancreatic cancer. Our study has shown evidence that Histone acetylation such as H3K9Ac and H3K27Ac is activated in pancreatic cancer cell lines. Furthermore, C646, which is a biological inhibitor of Histone acetylation, inhibited cell cycle and induced cell apoptosis of pancreatic cancer cell lines as well. Cell cycle related genes of cyclin B1 and CDC2 were also inhibited by C646 treatment. These data suggested that down-regulation of Histone acetylation induced G2/M cell cycle arrest through inhibition of cell cycle related genes at transcriptional level.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Products Report
  • Research Products

    (5 results)

All 2021 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results)

  • [Int'l Joint Research] ミシガン州立大学外科(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumoreffects in pancreatic cancer2021

    • Author(s)
      Hiroaki Ono, Tomotaka Kato, Yoshiki Murase, Yutaro Nakamura, Yoshiya Ishikawa, Shuichi Watanabe, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Daisuke Ban, Atsushi Kudo, Yoshimitsu Akiyama, Shinji Tanaka, Hiromichi Ito, Minoru Tanabe
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 10078-10078

    • DOI

      10.1038/s41598-021-89530-8

    • Related Report
      Products Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] P300 inhibition enhances gemcitabine-induced apoptosis of pancreatic cancer2016

    • Author(s)
      Hiroaki Ono
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 32 Pages: 51301-51310

    • DOI

      10.18632/oncotarget.10117

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ヒストンアセチル基転移酵素阻害剤 C646 はG2/M細胞周期停止を介し膵臓癌細胞株に おける細胞増殖を抑制する2017

    • Author(s)
      小野宏晃 伊藤寛倫 稲澤譲治 田邉稔
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒストンアセチル化阻害による膵臓癌の細胞 周期とジェムザール感受性への影響と解析2017

    • Author(s)
      小野宏晃 Marc Basson 田邉稔 伊藤寛倫
    • Organizer
      第48回日本膵臓学会
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2022-04-15  

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