A novel mechanism of TMJ-OA based on lubricin metabolism regulation
| Project/Area Number |
16H06778
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IKEDA Yuhei 東京医科歯科大学, 歯学部附属病院, 医員 (50778511)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 成長期 / 咀嚼刺激低下 / 変形性顎関節症 / ルブリシン / 細胞・組織 / 歯学 / 顎関節OA / 機械的負荷 / 潤滑機能 |
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| Outline of Final Research Achievements |
It is noticeable that temporomandibular joint (TMJ) hypofunction through mastication during the growth period is related to the development and progression of TMJ-OA due to deformity of the joints, muscular weakness, instability, overloading and so on.
In this study, 5-week-old male rats received a powder diet and forced to move left their jaws from 9 weeks of age. Compared with the control group, there was a tendency to increase in superficial cartilage in the lateral side of the condyle with toluidine blue staining. It also showed a tendency to increase lubricin immunopositive sites in the same regions with immunohistochemistry of lubricin .
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Report
(3 results)
Research Products
(6 results)
