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Evaluation of porous luminal structure beta-TCP with growth factor and development of new bone substitute materials

Research Project

Project/Area Number 16H06780
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Periodontology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

IKAWA Takahiro  東京医科歯科大学, 大学院医歯学総合研究科歯周病学分野, 非常勤講師 (20780290)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨補填剤 / 歯周組織再生 / 再生医療 / インプラント / 成長因子 / 骨再生 / 歯周病 / 骨補填材 / 再生医学 / 歯学 / 生体材料 / 組織工学
Outline of Final Research Achievements

Bone substitute materials are indispensable for periodontal regeneration and implant treatment. This study evaluated histologically localized ridge augmentation using different structures of β-TCP including luminal structure β-TCP blocks, dense β-TCP blocks, and β-TCP granule. Though we couldn't develop the new bone substitute materials, luminal structure may have a greater potential for new bone formation. We successfully showed that FGF-2 in gelatin/β-TCP sponges increased potential to support periodontal wound healing.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (8 results)

All 2018 2017

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Book (4 results)

  • [Journal Article] Histological healing after nonsurgical periodontal treatment with enamel matrix derivatives in canine experimental periodontitis2018

    • Author(s)
      Shujaa Addin Ammar、Akizuki Tatsuya、Matsuura Takanori、Hoshi Shu、Ikawa Takahiro、Maruyama Kiichi、Ono Wataru、Fukuba Shunsuke、Izumi Yuichi
    • Journal Title

      Odontology

      Volume: - Issue: 3 Pages: 1-8

    • DOI

      10.1007/s10266-018-0347-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biodegradable gelatin/beta-tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor-2 for treatment of recession-type defects: A split-mouth study in dogs.2017

    • Author(s)
      Shujaa Addin A, Akizuki T, Hoshi S, Matsuura T, Ikawa T, Fukuba S, Matsui M, Tabata Y, Izumi Y.
    • Journal Title

      J Periodontal Res. 2017

      Volume: 印刷中 Issue: 5 Pages: 863-871

    • DOI

      10.1111/jre.12456

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Ridge augmentation using tunnel beta-tricalcium phosphate block in dogs.2017

    • Author(s)
      Takahiro Ikawa, Tatsuya Akizuki, Ammar Shujaa Addin, Takanori Matsuura, Shu Hoshi, Shunsuke Fukuba, Yuichi Izumi
    • Organizer
      IADR/AADR/CADR GENERAL SESSION & EXHIBITION
    • Place of Presentation
      San Francisco (United States of America)
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of three-dimensional morphological changes in teeth extraction sites after ridge augmentationusing Bio-Oss and Bio-Gide; a six-month clinical study.2017

    • Author(s)
      Takahiro Ikawa, Tatsuya Akizuki, Kiichi Maruyama, Wataru Ono, Ammar Shujaa Addin, Yuichi Izumi.
    • Organizer
      National Symposium Osteology Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 月刊 日本歯科評論2018

    • Author(s)
      和泉雄一、井川貴博、大津杏里
    • Publisher
      Hyoron
    • Related Report
      2017 Annual Research Report
  • [Book] 歯周外科の基本テクニック 術前検査からメインテナンスまで2017

    • Author(s)
      和泉雄一、小田茂、菊池重成、秋月達也 他
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2017 Annual Research Report
  • [Book] 垂直的および水平的歯槽堤増大術 ソーセージテクニックと新たなコンビネーショングラフト2017

    • Author(s)
      和泉雄一、窪木拓男、山崎長郎
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2017 Annual Research Report
  • [Book] 【インプラント・ガイデッドサージェリーの現状】 デンツプロイシロナ GALILEOS Implantシステムの特徴と臨床の現状 簡単・迅速・安価を可能にしたシステム2017

    • Author(s)
      矢野 章, 井川貴博, 和泉雄一
    • Publisher
      日本歯科理工学会誌
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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