Big data applications for the prevention of non-communicable diseases

• Project/Area Number: 16H06808
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Niigata University
• Principal Investigator: Fujihara Kazuya 新潟大学, 医歯学総合研究科, 特任准教授 (10779341)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 医療ビッグデータ / データサイエンス / レセプト / 糖尿病 / 代謝異常 / 冠動脈疾患 / 生活習慣病 / 耐糖能障害 / ビックデータ / レセプトデータベース

Outline of Final Research Achievements

We analyzed data using a nationwide claim-based database in Japan consisting of approximately 3,000,000 people who belong to a health insurance provider. We evaluated the impact of prediabetes and diabetes on the development to CAD in Japanese men. Although diabetes was found to be associated with a 2-4 fold increased risk of CAD, our findings indicate that this consensus among diabetes specialists was limited to patients over 40 years of age. This study showed that diabetes confers about a 20-fold excess risk for CAD, independently from other conventional risk factors in men aged 31-40 years. Also, we showed that an metabolically unhealthy state can associate with CAD independently of obesity across all glucose tolerance stages.

Research Products

• [Journal Article] Cardiovascular Disease in Japanese Patients with Type 2 Diabetes Mellitus (2018)
  • Author(s): Fujihara K, Sone H
  • Journal Title: Annals of Vascular Diseases Volume: 11 Issue: 1 Pages: 2-14
  • DOI: 10.3400/avd.ra.17-00109
  • NAID: 130006549682
  • ISSN: 1881-641X, 1881-6428
  • Peer Reviewed / Open Access
• [Journal Article] Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2. (2018)
  • Author(s): Morikawa SY, Fujihara K, Hatta M, Osawa T, Ishizawa M, Yamamoto M, Furukawa K, Ishiguro H, Matsunaga S, Ogawa Y, Shimano H, Sone H.
  • Journal Title: Pediatr Diabetes. Volume: 印刷中 Issue: 4 Pages: 593-602
  • DOI: 10.1111/pedi.12623
  • Peer Reviewed / Open Access
• [Journal Article] Predictors of the response of HbA1c and body weight after SGLT2 inhibition. (2018)
  • Author(s): Abe T, Matsubayashi Y, Yoshida A, Suganami H, Nojima T, Osawa T, Ishizawa M, Yamamoto M, Fujihara K, Tanaka S, Kaku K, Sone H.
  • Journal Title: Diabet Metab. Volume: 44(2) Issue: 2 Pages: 172-174
  • DOI: 10.1016/j.diabet.2017.10.003
  • Peer Reviewed / Open Access
• [Journal Article] Meat intake and incidence of cardiovascular disease in Japanese patients with type 2 diabetes: analysis of the Japan Diabetes Complications Study (JDCS). (2018)
  • Author(s): Horikawa C, Kamada C, Tanaka S, Tanaka S, Araki A, Ito H, Matsunaga S, Fujihara K, Yoshimura Y, Ohashi Y, Akanuma Y, Sone H, Japan Diabetes Complications Study Group.
  • Journal Title: Eur J Nutr. Volume: 印刷中 Issue: 1 Pages: 281-90
  • DOI: 10.1007/s00394-017-1592-y
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis (2018)
  • Author(s): Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K, Hanyu O, Sone H.
  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 1 Pages: 3-18
  • DOI: 10.2188/jea.JE20160151
  • NAID: 130006301960
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Role of fatty liver in the association between obesity and reduced hepatic insulin clearance. (2018)
  • Author(s): Matsubayashi Y, Yoshida A, Suganami H, Ishiguro H, Yamamoto M, Fujihara K, Kodama S, Tanaka S, Kaku K, Sone H.
  • Journal Title: Diabetes Metab. Volume: 44(2) Issue: 2 Pages: 135-142
  • DOI: 10.1016/j.diabet.2017.12.003
  • Peer Reviewed / Open Access
• [Journal Article] 糖尿病患者における薬物処方の現状と多剤処方 (2018)
  • Author(s): 藤原和哉，曽根博仁
  • Journal Title: カレントテラピー Volume: 36 Pages: 55-60
• [Journal Article] Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42) (2017)
  • Author(s): Fujihara K, Igarashi R, Matsunaga S, Yamada T, Yokoyama H, Tanaka S, Shimano H, Maegawa H, Yamazaki K, Kawai K, Sone H
  • Journal Title: Medicine Volume: 96(7):e6122 Issue: 7 Pages: e6122-e6122
  • DOI: 10.1097/md.0000000000006122
  • NAID: 120005997848
  • Peer Reviewed / Open Access
• [Journal Article] Impact of body mass index and metabolic phenotypes on coronary artery disease according to glucose tolerance status. (2017)
  • Author(s): Fujihara K, Matsubayashi Y, Yamamoto M, Osawa T, Ishizawa M, Kaneko M, Matsunaga S, Kato K, Seida H, Yamanaka N, Kodama S, Sone H
  • Journal Title: Diabetes Metab. Volume: 43(6) Issue: 6 Pages: 543-546
  • DOI: 10.1016/j.diabet.2017.08.002
  • Peer Reviewed
• [Journal Article] Impact of glucose tolerance status on the development of coronary artery disease among working-age men (2017)
  • Author(s): Fujihara K, Igasashi R, Yamamoto M, Ishizawa M, Matsubayashi Y, Matsunaga S, Kato K, Ito C, Koishi M, Yamanaka N, Kodama S, Sone H
  • Journal Title: Diabetes Metab Volume: 印刷中 Issue: 3 Pages: 261-264
  • DOI: 10.1016/j.diabet.2016.09.001
  • Peer Reviewed / Open Access
• [Journal Article] Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS). (2017)
  • Author(s): Matsunaga S, Tanaka S, Fujihara K, Horikawa C, Iimuro S, Kitaoka M, Sato A, Nakamura J, Haneda M, Shimano H, Akanuma Y, Ohashi Y, Sone H.
  • Journal Title: J Psychosom Res. Volume: 99 Pages: 34-39
  • DOI: 10.1016/j.jpsychores.2017.05.020
  • Peer Reviewed / Open Access
• [Journal Article] Unstable body weight and incident type 2 diabetes mellitus - A meta-analysis (in press) (2017)
  • Author(s): Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K, Hanyu O, Sone H
  • Journal Title: Journal of diabetes investigation Volume: - Issue: 4 Pages: 501-509
  • DOI: 10.1111/jdi.12623
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 耐糖能と肺機能の関連 (2017)
  • Author(s): 藤原和哉
  • Journal Title: 糖尿病合併症 Volume: 31 Pages: 160-2
• [Journal Article] 日本人糖尿病合併症の特徴 (2017)
  • Author(s): 藤原和哉，曽根博仁
  • Journal Title: 月刊糖尿病 Volume: 6 Pages: 93-102
• [Journal Article] Reversible splenial lesion syndrome with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome caused by olanzapine (2017)
  • Author(s): Kaino K, Kumagai R, Furukawa S, Isono M, Muramatsu A, Fujii M, Muta Y, Asada T, Fujihara K, Yagyu H
  • Journal Title: J Diabetes Investig Volume: 8 Issue: 3 Pages: 392-394
  • DOI: 10.1111/jdi.12597
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of individual components and their combinations within a family history of hypertension on the incidence of hypertension: Toranomon hospital health management center study 22 (2016)
  • Author(s): Igarashi R, Furukawa K, Heianza Y, Ishizawa M, Kodama S, Saito K, Hara S, Hanyu O, Honda R, Tsuji H, Arase Y, Sone H
  • Journal Title: Medicine Volume: 95(38):e4564 Issue: 38 Pages: e4564-e4564
  • DOI: 10.1097/md.0000000000004564
  • Peer Reviewed / Open Access
• [Journal Article] Utility of nonblood-based risk assessment for predicting type 2 diabetes mellitus: A meta-analysis (2016)
  • Author(s): Yoshizawa S, Kodama S, Fujihara K, Ishiguro H, Ishizawa M, Matsubayashi Y, MatsunagaS, Yamada T, Shimano H, Kato K, Hanyu O, Sone H
  • Journal Title: Prev Med Volume: 91 Pages: 180-187
  • DOI: 10.1016/j.ypmed.2016.07.026
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative assessment of genetic testing for type 2 diabetes mellitus based on findings of genome-wide association studies (2016)
  • Author(s): Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K, Hanyu O, Sone H
  • Journal Title: Am J Surg Pathol Volume: 11 Issue: 11 Pages: 816-818
  • DOI: 10.1016/j.annepidem.2016.09.004
  • Peer Reviewed / Open Access
• [Journal Article] Association of eating three meals irregularly with changes in BMI and weight among young Japanese men and women: A 2-year follow-up (2016)
  • Author(s): Ibe Y, Miyakawa H, Fuse-Nagase Y, Hirose S. A, Hirasawa R, Yachi Y, Fujihara K, Kobayashi K, Shimano H, Sone H
  • Journal Title: Physiol Behav Volume: 163 Pages: 81-87
  • DOI: 10.1016/j.physbeh.2016.04.045
  • Peer Reviewed / Open Access
• [Journal Article] 食前だけではなく食後の脂質代謝にも目を向けたコントロールを (2016)
  • Author(s): 藤原和哉
  • Journal Title: Diabetes strategy Volume: 6 Pages: 24-24
• [Presentation] 勤労世代男性における各耐糖能が冠動脈疾患発症に及ぼす影響の検討 (2018)
  • Author(s): 藤原 和哉,松林 泰弘,山本 正彦,石澤 正博,松永 佐澄志,山田 貴穂,山中 菜詩,清田 浩康, 児玉 暁, 曽根 博仁
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 医療ビックデータを活用した糖尿病患者における冠動脈疾患の検討 (2018)
  • Author(s): 藤原 和哉
  • Organizer: 第55回日本糖尿病学会関東甲信越地方会
  • Invited
• [Presentation] 働き盛り世代男性における耐糖能の冠動脈疾患発症への影響の検討 (2017)
  • Author(s): 藤原 和哉,五十嵐 理沙,山本 正彦,石澤 正博,松林 泰弘,松永 佐澄志,加藤 公則,伊藤 知恵,小石 美恵子,山中 菜詩,児玉 暁,曽根 博仁
  • Organizer: 第51回日本成人病（生活習慣病）学会
  • Place of Presentation: 都市センターホテル(東京都千代田区)
  • Year and Date: 2017-01-15
• [Presentation] 働き盛り世代男性における耐糖能の冠動脈疾患発症への影響の検討 (2017)
  • Author(s): 藤原 和哉,五十嵐 理沙,山本 正彦,石澤 正博,松林 泰弘,松永 佐澄志,加藤 公則,伊藤 知恵,小石 美恵子,山中 菜詩,児玉 暁,曽根 博仁
  • Organizer: 第51回日本成人病（生活習慣病）学会学術集会
• [Presentation] 勤労世代男性における耐糖能の冠動脈疾患発症への影響の検討 (2017)
  • Author(s): 藤原 和哉,山本 正彦,石澤 正博,松林 泰弘,松永 佐澄志,山田 貴穂,加藤 公則,伊藤 知恵,小石 美恵子,山中 菜詩,曽根 博仁
  • Organizer: 第90回日本内分泌学会学術総会
• [Presentation] わが国の糖尿病専門医の薬物療法における処方と患者背景の解析（第3報） (2017)
  • Author(s): 藤原 和哉,五十嵐 理沙,松永 佐澄志,松林 泰弘,山田 貴穂,横山 宏樹,田中 司朗,島野 仁,前川 聡,山 崎 勝也,川井 紘一,曽根 博仁
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 耐糖能別にみた収縮期血圧が透析導入に及ぼす影響の検討 (2017)
  • Author(s): 古谷篤、藤原和哉、五十嵐理沙、山本正彦、石澤正博、松林泰弘、松永佐澄志、加藤公則、伊藤知恵、小石美恵子、山中詩菜、児玉暁、曽根博仁
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 糖尿病に起因する重症視力障害発症のリスク検討およびHbA1cの閾値に関する検討 (2017)
  • Author(s): 山本正彦、藤原和哉、伊藤知恵、錦野理絵、山中詩菜、児玉暁、長谷部日、田中司朗、曽根博仁
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 糖尿病患者における透析導入のリスク因子の検討 (2017)
  • Author(s): 大澤妙子、山本正彦、石澤正博、松林泰弘、松永佐澄志、藤原和哉、山田貴穂、小石美恵子、伊藤知恵、山中詩菜、児玉暁、加藤公則、曽根博仁
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] Impact of Obesity and Metabolic Phenotypes on Coronary Artery Disease (CAD) According to Glucose Tolerance Status (2017)
  • Author(s): Kazuya Fujihara, Satoru Kodama, Masahiko Yamamoto, Satoshi Matsunaga, Yasuhiro Matsubayasi, Masahiro Ishizawa, Mieko Koishi, Chie Ito, Nauta Yamanaka, Kiminori Kato, Hirohito Sone
  • Organizer: 77th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Associations between Hypertension and End-Stage Renal Disease (ESRD) in People With and Without Diabetes (2017)
  • Author(s): Furuya A, Fujihara K, Ishizawa M, Yamamoto M, Matsubayashi Y, Matsunaga S, Ito C, Koishi M, Yamanaka N, Kato K, Kodama S, Sone H
  • Organizer: 77th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Pulse Pressure and HbA1c Levels Are Significant Predictors of Vision-Threatening Eye Diseases in Japanese Patients with Diabetes Mellitus (2017)
  • Author(s): Yamamoto M, Fujihara K, Igarashi R, Yoshizawa S, Matsubayashi Y, Yamada T, Matsunaga S, Ito C, Yamanaka N, Hasebe H, Fukuchi T, Tanaka S, Kato K, Kodama S, Sone H
  • Organizer: 77th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Effects on Fasting Free Fatty Acid (F-FFA) and Adipose-Tissue Insulin Resistance (Adipo-IR) after Long-Term Treatment of Type 2 Diabetes Mellitus (T2DM) with the SGLT2 inhibitor (SGLT2i) Tofogliflozin (TOFO) (2017)
  • Author(s): Matsubayashi Y, Yoshida A, Suganami H, Fujihara K, Kaku K, Sone H
  • Organizer: 77th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Impact of Individual Components and Their Combinations within a Family History (FH) of Diabetes on the Development of Diabetes (2017)
  • Author(s): Igarashi R, Ishii D, Takeda Y, Fujihara K, Hatta M, oshikane Y, Matsubayashi Y, Saito K, Kodama S, Honda R, Arase Y, Sone H
  • Organizer: 77th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Trends In Dietary Intake by Patients with Type 2 Diabetes (T2DM) in Japan, 1996-2016 (2017)
  • Author(s): Takeda Y, Horikawa C, Tsuruta M, Fujihara K, Yoshizawa S, Igarashi R, Hatta M, Ishii D, Kato M, Yokoyama H, Kurihara Y, Miyazawa K, Iwasaki K, Kawai K, Tomonaga O, Yagi N, Maegawa H, Sone H, Japan Diabetes Clinical Data Management Study Group
  • Organizer: 77th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] 医療ビックデータを活用した新潟発の臨床疫学研究 (2017)
  • Author(s): 藤原和哉, 曽根博仁
  • Organizer: 第724回新潟医学会
  • Invited
• [Presentation] Big data applications in diabetes and cardiovascular disease (2017)
  • Author(s): Fujihara K
  • Organizer: he 21st International Epidemiological Association (IEA) World Congress of Epidemiology
  • Int'l Joint Research / Invited
• [Presentation] 医療ビッグデータを活用した耐糖能と冠動脈疾患および糖尿病重症合併症に関連するリスク因子の検討 (2017)
  • Author(s): 藤原 和哉,松林 泰弘,山本 正彦, 大澤 妙子, 長谷部 日, 清田 浩康, 山中 菜詩, 田中 司朗, 児玉 暁, 曽根 博仁
  • Organizer: 日本臨床疫学会 第1回年次学術大会
• [Presentation] 糖尿病が冠動脈疾患発症へ与える影響は若年者と中年では大きく異なる (2017)
  • Author(s): 藤原 和哉,松林 泰弘,,山本 正彦,石澤 正博,松永 佐澄志,山田 貴穂, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁
  • Organizer: 第32回日本糖尿病合併症学会
• [Presentation] 糖尿病重症視力障害発症とHbA1cの関連性についての検討 (2016)
  • Author(s): 山本正彦、藤原和哉、五十嵐理沙、石澤正博、松林泰弘、松永佐澄志、伊藤知恵、錦野理絵、山中菜詩、児玉暁、曽根博仁
  • Organizer: 第22回日本糖尿病眼学会総会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-10-07
• [Presentation] 耐糖能と肺機能の関連 (2016)
  • Author(s): 藤原 和哉
  • Organizer: 第31回 日本糖尿病合併症学会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] Impact of glucose tolerance status on development of coronary artery disease among working aged men in Japan (2016)
  • Author(s): Fujihara K, Yamanaka N, Nishikino R, Yamamoto M, Matsubayashi Y, Matsunaga S, Yamada T, Ishiguro H, Horikawa C, Ishizawa M, Ohara N, Kato K, Sone H
  • Organizer: European Association for the Study of Diabetes(EASD)
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-09-12
• [Presentation] Meta-analysis of improvement in glycaemic control by family intervention in patients with diabetes mellitus (2016)
  • Author(s): Tsuruta M, Kodama S, Fujihara K, Ishiguro H, Igarashi R, Yamamoto M, Ishizawa M, Horikawa C, Yoshizawa S, Sone H
  • Organizer: European Association for the Study of Diabetes(EASD)
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-09-12
• [Presentation] Distance between dietary intake and self-rated dietary behavior in patients with diabetes: analysis from National Health and Nutrition survey in Japan (2016)
  • Author(s): Horikawa C, Murayama N, Tsuruta M, Oshikane Y, Hirasawa R, Yachi Y, Fujihara K, Hanyu O, Sone H
  • Organizer: European Association for the Study of Diabetes(EASD)
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-09-12
• [Book] 糖尿病と循環器病 一歩進んだ糖尿病循環器学 Diabetic Cardiology (2017)
  • Author(s): 藤原和哉，曽根博仁
  • Total Pages: 12
  • Publisher: 医薬ジャーナル社
  • ISBN: 9784753228379
• [Book] 糖尿病と循環器病 一歩進んだ糖尿病循環器学 ～Diabetic Cardiology～ (2017)
  • Author(s): 藤原和哉，曽根博仁
  • Total Pages: 12
  • Publisher: 医薬ジャーナル社