A role of actin remodeling in cortical interneuron for critical period plasticity

• Project/Area Number: 16H06811
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Niigata University
• Principal Investigator: Hou Xubin 新潟大学, 医歯学総合研究科, 特任助教 (00584765)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 抑制性介在ニューロン / 細胞骨格 / 眼優位性可塑性 / 臨界期 / アクチン細胞骨格 / Otx2 / ocular dominance / dendritic morphology / synapse formation / Coactosin

Outline of Final Research Achievements

Binocular vision is established in the primary visual cortex (V1) through activity-dependent competition during early postnatal life. Ocular dominance plasticity accompanies with maturation of cortical GABA circuits. We have found that Otx2 homeoprotein regulates the critical period via promoting perineuronal nets (PNNs) formation that strengthened visual responses on parvalbumin-positive interneurons (PV-cells). Otx2-inducible actin reorganization factor, Coactosin play a constructive role in maturation of PV circuits, ultimately regulating the cortical milieu for plasticity.

Research Products

• [Journal Article] Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex (2017)
  • Author(s): Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12646-12646
  • DOI: 10.1038/s41598-017-04007-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex (2017)
  • Author(s): Sakai Akiko、Nakato Ryuichiro、Ling Yiwei、Hou Xubin、Hara Norikazu、Iijima Tomoya、Yanagawa Yuchio、Kuwano Ryozo、Okuda Shujiro、Shirahige Katsuhiko、Sugiyama Sayaka
  • Journal Title: Frontiers in Neuroscience Volume: 11 Pages: 307-307
  • DOI: 10.3389/fnins.2017.00307
  • Peer Reviewed / Open Access
• [Journal Article] Chondroitin Sulfate within Perineuronal Nets Is Required for Onset and Offset of Critical Period Plasticity in the Visual Cortex (2017)
  • Author(s): Xubin Hou, Nozomu Yoshioka, Hiroaki Tsukano, Akiko Sakai, Shinji Miyata, Yumi Watanabe, Yuchio Yanagawa, Kenji Sakimura, Kosei Takeuchi, Hiroshi Kitagawa, Takao K Hensch, Katsuei Shibuki, Michihiro Igarashi and Sayaka Sugiyama
  • Journal Title: Scientific Reports Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 臨界期抑制性介在ニューロンの形態形成機構の解明 (2018)
  • Author(s): 侯 旭濱, 國見 順子, 﨑村建司, 杉山清佳
  • Organizer: 第8回新潟大学脳研究所共同研究拠点国際シンポジウム
  • Int'l Joint Research
• [Presentation] Coactosin, an actin-remodeling factor promotes maturation of parvalbumin-positive cells for cortical plasticity (2017)
  • Author(s): Xubin Hou, Kenji Sakimura and Sayaka Sugiyama
  • Organizer: 第10回神経発生討論会
  • Place of Presentation: 秋保リゾートホテルクレセント(宮城県仙台市)
  • Year and Date: 2017-03-10
  • Int'l Joint Research / Invited
• [Presentation] 臨界期における抑制性介在ニューロンのアクチン再構築の役割え (2017)
  • Author(s): 侯 旭濱, 﨑村 建司, 杉山 清佳
  • Organizer: 第40回日本神経科学会
  • Int'l Joint Research
• [Presentation] アクチン再編因子Coactosinによる臨界期PV陽性細胞の成熟促進 (2017)
  • Author(s): 侯 旭濱, 﨑村 建司, 杉山 清佳
  • Organizer: 第10回神経発生討論会