A role of actin remodeling in cortical interneuron for critical period plasticity
Project/Area Number |
16H06811
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Niigata University |
Principal Investigator |
Hou Xubin 新潟大学, 医歯学総合研究科, 特任助教 (00584765)
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Project Period (FY) |
2016-08-26 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 抑制性介在ニューロン / 細胞骨格 / 眼優位性可塑性 / 臨界期 / アクチン細胞骨格 / Otx2 / ocular dominance / dendritic morphology / synapse formation / Coactosin |
Outline of Final Research Achievements |
Binocular vision is established in the primary visual cortex (V1) through activity-dependent competition during early postnatal life. Ocular dominance plasticity accompanies with maturation of cortical GABA circuits. We have found that Otx2 homeoprotein regulates the critical period via promoting perineuronal nets (PNNs) formation that strengthened visual responses on parvalbumin-positive interneurons (PV-cells). Otx2-inducible actin reorganization factor, Coactosin play a constructive role in maturation of PV circuits, ultimately regulating the cortical milieu for plasticity.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex2017
Author(s)
Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 12646-12646
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Chondroitin Sulfate within Perineuronal Nets Is Required for Onset and Offset of Critical Period Plasticity in the Visual Cortex2017
Author(s)
Xubin Hou, Nozomu Yoshioka, Hiroaki Tsukano, Akiko Sakai, Shinji Miyata, Yumi Watanabe, Yuchio Yanagawa, Kenji Sakimura, Kosei Takeuchi, Hiroshi Kitagawa, Takao K Hensch, Katsuei Shibuki, Michihiro Igarashi and Sayaka Sugiyama
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Journal Title
Scientific Reports
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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