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摂食運動時における口腔感覚の変調

Research Project

Project/Area Number 16H06816
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNiigata University

Principal Investigator

酒井 翔悟  新潟大学, 医歯学総合病院, 医員 (10783350)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Declined (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯科 / 開口反射 / 三叉神経 / 嚥下 / 生理学 / 歯学 / 動物
Outline of Annual Research Achievements

本研究では,麻酔動物を用いた以下の電気生理学的実験を進めた.嚥下運動誘発のために上喉頭神経ならびに皮質嚥下関連刺激を行い,その際に三叉神経核ニューロンの活動が変調するか否かを記録した.また,筋活動の興奮性を評価する目的で下歯槽神経刺激によって得られた開口反射の振幅の変化を記録した.
その結果,いずれの嚥下誘発刺激によっても神経活動や開口反射は抑制され,その抑制は刺激後も継続した.三叉神経ニューロンの記録部位は,三叉神経運動核周囲に及んでいたが,局在を明らかにするところまでは至らなかった.
さらに視床ニューロン活動が嚥下誘発刺激によっていかなる変調を受けるかの実験を開始したものの,これまでに変調を受けるニューロンは見つかっていない.

Research Progress Status

翌年度、交付申請を辞退するため、記入しない。

Strategy for Future Research Activity

翌年度、交付申請を辞退するため、記入しない。

Report

(1 results)
  • 2016 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Central inhibition of initiation of swallowing by systemic administration of diazepam and baclofen in anaesthetized rats2017

    • Author(s)
      Tsujimura T, Sakai S, Suzuki T, Ujihara I, Tsuji K, Magara J, BJ Canning, Inoue M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 印刷中 Issue: 5 Pages: G498-G507

    • DOI

      10.1152/ajpgi.00299.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Effects of peripherally and centrally-evoked swallow on the jaw reflex responses2017

    • Author(s)
      Suzuki T, Sakai S, Tsuji K, Magara J, Tsujimura T, Inoue M
    • Organizer
      The Dysphagia Research Society 25th Annual Meeting
    • Place of Presentation
      Hilton & Executive Tower (Portland), USA
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of jaw reflex responses during peripherally and centrally-evoked swallow2017

    • Author(s)
      Suzuki T, Sakai S, Tsuji K, Magara J, Tsujimura T, Inoue M
    • Organizer
      International collaborative symposium on development of human resources in practical oral health and treatment
    • Place of Presentation
      Manathai Koh Samui, (Koh Samui) Thailand
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of electrical stimulation of the superior laryngeal nerve and cortical swallowing areas on the jaw-opening reflex2016

    • Author(s)
      Suzuki T, Sakai S, Tsuji K, Magara J, Tsujimura T, Inoue M
    • Organizer
      Soceity for Neuroscience
    • Place of Presentation
      San Diego Convention Center (San Diego), USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2016-09-02   Modified: 2018-01-16  

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