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Analysis of pain mechanism focused on prostaglandin I2 during orthodontic tooth movement

Research Project

Project/Area Number 16H06818
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNiigata University

Principal Investigator

Ohkura Mariko  新潟大学, 医歯学総合病院, 医員 (50779634)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsプロスタグランジンI2 / TRPV1 / 矯正 / 疼痛 / IP受容体 / PGIS / IP
Outline of Final Research Achievements

This study attempted to analyze the mRNA and protein expression of prostaglandin I2 synthase, IP receptor, and TRPV1 with real-time PCR and immunohistostaining in experimental force-applied rat molar pulp tissue. PGIS was immunolocalized in odontoblasts and some fibroblasts in the forced-stimulated pulp. The IP receptor and TRPV1 were detected on odontoblasts and some neuron fibers. It was conclude that PGIS, IP receptor, and TRPV1 in rat molar pulp were significantly upregulated shortly after the force application, and that the IP receptor was co-expressed on TRPV1 expressing nerves and odontoblasts. These findings suggest that the PGI2-IP receptor-TRPV1 pathway is associated with the acute phase of force induced pulp changes involving odontoblasts and nerves.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (4 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Orthodontic forc application upregulated pain-associated prostaglanidn=2/PGI2-receptor/TRPV1 pathway-related gene expression in rat molars2018

    • Author(s)
      Mariko Ohkura, Naoto Ohkura, Nagako Yoshiba, Kunihiko Yoshiba, Hiroko Ida-Yonemochi, Hayato Ohshima, Isao Saito, Takashi Okiji
    • Journal Title

      Odontology

      Volume: 160(1) Issue: 1 Pages: 2-10

    • DOI

      10.1007/s10266-017-0309-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Orthodontic force application upregulated pain-associated prostaglandin-I2/PGI2-receptor/TRPV1 pathway-related gene expression in rat molars.2017

    • Author(s)
      Ohkura M, Ohkura N, Yoshiba N, Yoshiba K, Ida-Yonemochi H, Ohshima H, Saito I, Okiji T
    • Journal Title

      Odontology

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 矯正的歯の移動におけるprostaglandin I2合成酵素の発現解析と3次元的応力分布解析2017

    • Author(s)
      大倉麻里子, 大倉直人, 丹原 惇, 藤田 瑛, 野杁由一郎, 齋藤 功
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 実験的歯の移動時におけるラット臼歯歯髄内 Prostaglandin I2合成酵素とIP受容体の発現解析2016

    • Author(s)
      大倉麻里子, 大倉直人, 野杁由一郎, 齋藤 功
    • Organizer
      第75回日本矯正歯科学会学術大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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