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Development of novel phototriggered reactions and their application to biomolecule labeling

Research Project

Project/Area Number 16H06824
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionKanazawa University

Principal Investigator

Mishiro Kenji  金沢大学, 新学術創成研究機構, 助教 (60776079)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords光化学反応 / 有機化学物質 / 光物性 / 生理活性 / 光反応 / 生理活性物質 / 有機化学
Outline of Final Research Achievements

In this research we have accomplished two types of project using highly strained molecules. First project was the development of novel bioactive compounds having highly strained structure. We have succeeded to synthesis the desired product and analysed its activity and biodistribution using nuclear medicine method. We have obtained some important information for the medicinal chemistry using the strained structures. Second project was the development of novel phototriggered reactions using highly strained molecules. We have succeeded to develop a phototriggered dehydration condensation whose progress is completely controllable by ON/OFF states of the light irradiation. The result was published in Org. Lett. 2017, 4912.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Int'l Joint Research] Columbia University(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Phototriggered Dehydration Condensation Using an Aminocyclopropenone2017

    • Author(s)
      Mishiro Kenji、Yushima Yuki、Kunishima Munetaka
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 18 Pages: 4912-4915

    • DOI

      10.1021/acs.orglett.7b02383

    • NAID

      120006374165

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] アミノシクロプロペノンを用いる光活性化型脱水縮合反応の開発2017

    • Author(s)
      湯島 悠貴,三代 憲司,国嶋 崇隆
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis and evaluation of radiotracers for PDGFR beta imaging2016

    • Author(s)
      Nurmaya Effendy、小川 数馬、三代 憲司、北村陽二、柴和弘、小谷明
    • Organizer
      日本薬学会北陸支部平成28年度総会及び第128回例会
    • Place of Presentation
      金沢
    • Related Report
      2016 Annual Research Report
  • [Presentation] At-211 アルファ線治療を目指した放射性ハロゲン標識法の基礎的検討2016

    • Author(s)
      武田拓也、小川数馬、三代憲司、柴和弘、絹谷清剛、小谷明
    • Organizer
      日本薬学会北陸支部平成28年度総会及び第128回例会
    • Place of Presentation
      金沢
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2022-01-28  

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