| Project/Area Number |
16H06841
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
Tanaka Megumu 信州大学, 医学系研究科, 研究員 (90786401)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アドレノメデュリン / 腫瘍血管新生 / 血管恒常性 / 転移前土壌 / リンパ節転移 / 癌 / 生理活性 / 遺伝子 / 動物 |
|---|
| Outline of Final Research Achievements |
Adrenomedullin, a vasoactive peptide, and its receptor-modulating protein RAMP2 are expected to be therapeutic target for suppressing tumor metastasis. We established vascular endothelial cell-specific RAMP2 knockout mice (DI-E-RAMP2-/-) and lymphatic endothelial cell -specific RAMP2 knockout mice (DI-LE-RAMP2-/-), and evaluated the role of AM-RAMP2 system in tumor metastasis.
In DI-E-RAMP2-/-, primary tumor growth was suppressed, but lung metastasis was accelerated due to the disruption of vascular homeostasis. On the other hand, in DI-LE-RAMP2-/-, primary tumor growth was enhanced with accelerated tumor angiogenesis. We are now analyzing lymph node metastasis by tumor transplantation to the footpad.
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