| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We have previously identified a novel apoptosis suppressor Apsup from the baculovirus Lymantria dispar multiple nucleopolyhedrovirus (LdMNPV). Apsup suppresses apoptosis by preventing proteolytic processing of L. dispar initiator caspase Ld-Dronc. Here, we performed mutation analyses of Apsup to determine functional domains in Apsup. Mutation analyses indicated that the N-terminal region in Apsup required for interacting with Ld-Dronc, and the C-terminal region in Apsup required for preventing the proteolytic processing of Ld-Dronc. Our findings provide clues to understand the mechanisms by which Apsup suppresses apoptosis.
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