| Project/Area Number |
16H06867
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
KIMURA Hiroshi 名古屋大学, 大学院医学系研究科, 教授 (30303621)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | EBV / ヒト化マウス / ウイルス学 / ウィルス / EBV関連リンパ増殖症 / ヒト化マウスモデル / 腫瘍ウイルス / 感染症 |
|---|
| Outline of Final Research Achievements |
Epstein-Barr virus (EBV) is a member of gamma-herpesvirus, associated with lymphoproliferative disorders (LPDs) and malignant tumors. EBV has been studied extensively in vitro, but its in vivo analysis has not been sufficient. In this study, we established the humanized mouse model which enabled pathological analysis in a physiological setting. Severely immunodeficient mice transplanted with cord blood infected with EBV in vitro efficiently developed lymphoproliferative disorder. These findings suggested that this animal model was available for research of the pathogenic mechanism.
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