| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
RNA binding proteins (RBPs) play a central role in the fate decision of mRNA. Better understanding of dynamic changes in RBP-RNA interaction during inflammation is important for discovery of new post-transcriptional mechanisms. In this study, RBP-RNA interactome was determined using T cell line post-activation. I found that 750 RBPs were detected and that a gene cluster related to inflammatory responses was identified from among them. RBPs that are presumably involved in inflammatory responses were selected and I obtained preliminary data that these RBPs regulate inflammation including cytokine production. Collectively, I demonstrated that RBPs underwent a dynamic change in RNA interaction status during inflammation.
|
