The attempt to detect macrophage subsets specific for atherosclerotic plaque development and regression.

• Project/Area Number: 16H06901
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: NISHI HITOO 京都大学, 医学研究科, 特定准教授 (70583194)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 動脈硬化 / マクロファージ / 循環器・高血圧

Outline of Final Research Achievements

We have established a mouse model of atherosclerosis plaque progression and regression with gain of function mutation of Pcsk9 gene delivered by adeno-associated virus vector. In this model, hypercholesterolemia and subsequent atherosclerotic plaque formation can be easily induced in any genetically modified mice without crossbreeding with atherogenic ApoE- or LDLr-knockout animals.

Research Products

• [Journal Article] A wild-type mousebased model for the regression of inflammation in atherosclerosis. (2017)
  • Author(s): Peled-M*, Nishi-H*, Weinstock A, Barrett TJ, Zhou F, Quezada A, Fisher EA.
  • Journal Title: PLoS One. Volume: 12(3)
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A wild-type mouse-based model for the regression of inflammation in atherosclerosis (2017)
  • Author(s): Peled M, Nishi H, Weinstock A, Barret TJ, Zhou F, Quezada A, Fisher EA
  • Journal Title: Plos one Volume: 12 Issue: 3 Pages: e0173975-e0173975
  • DOI: 10.1371/journal.pone.0173975
  • Peer Reviewed / Open Access
• [Presentation] 動脈硬化退縮と炎症 (2017)
  • Author(s): 西 仁勇
  • Organizer: 日本動脈硬化学会