The attempt to detect macrophage subsets specific for atherosclerotic plaque development and regression.
| Project/Area Number |
16H06901
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
NISHI HITOO 京都大学, 医学研究科, 特定准教授 (70583194)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 動脈硬化 / マクロファージ / 循環器・高血圧 |
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| Outline of Final Research Achievements |
We have established a mouse model of atherosclerosis plaque progression and regression with gain of function mutation of Pcsk9 gene delivered by adeno-associated virus vector. In this model, hypercholesterolemia and subsequent atherosclerotic plaque formation can be easily induced in any genetically modified mice without crossbreeding with atherogenic ApoE- or LDLr-knockout animals.
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Report
(3 results)
Research Products
(3 results)
