| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
hepatocellular carcinoma cell line was engrafted in decellularized liver scaffold and characterized as cancer cell. As a result, it was found that the signl of epithelial-mesenchymal-transition was activated in decellularized scaffold derived from fibrous liver compared with that derived from normal liver. Adding to this, the FAK signal was activated as a mechanism. In other words, it was shown that the extracellular matrix in fibrotic liver may provide an environment susceptible to epithelial mesenchymal transition to cancer cells. From the above, it was shown that the hardness and constituent elements of the extracellular matrix affect the malignancy and metastatic potential of the cancer cells.
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