| Project/Area Number |
16H06906
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
Tomizawa Takuya
Morita Yugo
Saito Motoo
|
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| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | バイオフィルム / 骨髄炎 / インプラント / 化学療法 / 黄色ブドウ球菌 / 外科 / 感染症 / インプラント感染 / 整形外科学 |
|---|
| Outline of Final Research Achievements |
Effect of antibiotics for the prophylaxis and treatment of biofilm formation in murine tibial implant associated osteomyelitis was studied. The inhibitory effect of biofilm formation differed among antibiotics. Although vancomycin and gentamycin showed strong effect for the prophylaxis for biofilm formation, cefazolin showed weaker potential. For the treatment, the tread was similar, that is cefazolin was almost invalid for the treatment of biofilm. On the other hand, vancomycin or gentamycin reduced biofilm formation, if administrated one day after infection. No antibiotics was useful if administrated after 14 day. Treatment of biofilm infection with single antibiotics was not effective enough, and usage of multiple antibiotics should be studied in the future.
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