The mechanism of the prevention for dementia, focusing exercise therapy

Research Project

Project/Area Number	16H06910
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Gerontological nursing
Research Institution	Kyoto University
Principal Investigator	Noda Yasuha 京都大学, 医学研究科, 特定助教 (50784146)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	アルツハイマー病 / 運動療法 / 運動 / アミロイドβ
Outline of Final Research Achievements	Alzheimer's disease is the principal disease causing dementia, and has not been completely cured. So it's so important to avoid the development and delay the onset of AD. The association between AD and life style disease is widely reported. We consider that the improvement of lifestyle can be suppress the pathogenesis of AD. Especially, we focus on exercise-related molecule X. We analysis of the effect of molecule X for Aβ level, the most major cause in the AD pathology, furthermore we will reveal that by using intervention experiments using AD model mice.