Computational modeling of thrombus formation in coiled cerebral aneurysms

• Project/Area Number: 16H06917
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: Otani Tomohiro 大阪大学, 基礎工学研究科, 助教 (40778990)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 脳動脈瘤 / 数値流体計算 / 直交格子法 / コイル塞栓術 / 血栓 / 計算バイオメカニクス / 数値流体計算脳動脈瘤

Outline of Final Research Achievements

This study developed a computational framework to analyze the blood flow characteristics in densely coiled cerebral aneurysms and a numerical model of the thrombus formation in the coiled aneurysm by representing the mechanical interaction between the thrombus formation and blood flow stagnation. The computational framework allowed us to estimate effects of coil packing density and configurations on the extent of blood flow stagnation in the aneurysm statistically. Furthermore, the phenomenological model of the thrombus formation successfully expressed effects of the coil configuration on the extent of thrombus formation in densely coiled aneurysms.

Research Products

• [Journal Article] Effect of Local Coil Density on Blood Flow Stagnation in Densely Coiled Cerebral Aneurysms: A Computational Study Using a Cartesian Grid Method (2018)
  • Author(s): Otani Tomohiro、Shindo Takuya、Ii Satoshi、Hirata Masayuki、Wada Shigeo
  • Journal Title: Journal of Biomechanical Engineering Volume: 140 Issue: 4 Pages: 041013-041013
  • DOI: 10.1115/1.4039150
  • Peer Reviewed
• [Journal Article] Computational Study of the Non-Newtonian Effect of Blood on Flow Stagnation in a Coiled Cerebral Aneurysm (2017)
  • Author(s): Tomohiro Otani、Ii Satoshi、Hirata Masayuki、Wada Shigeo
  • Journal Title: Nihon Reoroji Gakkaishi Volume: 45 Issue: 5 Pages: 243-249
  • DOI: 10.1678/rheology.45.243
  • NAID: 130006513844
  • ISSN: 0387-1533, 2186-4586
  • Peer Reviewed / Open Access
• [Presentation] A computational framework to analyze the extent of blood flow stagnation in densely coiled cerebral aneurysms (2017)
  • Author(s): Tomohiro Otani, Satoshi Ii, Masayuki Hirata, Shigeo Wada
  • Organizer: 5th Switzerland-Japan workshop on Biomechanics 2017
  • Int'l Joint Research
• [Presentation] Computational Analysis of the Blood Flow Characteristics during Thrombus Formation in the Coiled Cerebral Aneurysm (2017)
  • Author(s): Tomohiro Otani, Satoshi Ii, Masayuki Hirata, Shigeo Wada
  • Organizer: XXVI Congress of the International Society of Biomechanics
  • Int'l Joint Research
• [Presentation] 直交格子法を用いた左心房内血流の患者個別解析 (2017)
  • Author(s): Tomohiro Otani, Hiroshi Ashikaga, Shigeo Wada
  • Organizer: 日本機械学会第30回バイオエンジニアリング講演会
• [Presentation] Toward a development of medical support simulator of endovascular coiling using high performance computing (2017)
  • Author(s): Tomohiro Otani, Shigeo Wada
  • Organizer: Fourteens International Conference of Flow Dynamics
  • Int'l Joint Research / Invited
• [Presentation] 大規模数値流体解析による左心房内血栓症の患者別リスク予測への挑戦 (2017)
  • Author(s): 大谷智仁
  • Organizer: 日本機械学会2017年度年次大会
  • Invited
• [Presentation] 計算力学解析によるコイル塞栓された脳動脈瘤の血栓化予測の試み (2017)
  • Author(s): 大谷智仁
  • Organizer: 日本機械学会バイオエンジニアリング部門 脳神経血管内治療に関する医工学連携研究会
  • Place of Presentation: 名古屋大学（愛知県・名古屋市）
  • Invited
• [Presentation] 循環器系疾患の患者個別治療にむけた計算力学解析の試み (2016)
  • Author(s): 大谷智仁
  • Organizer: 統計数理研究所 数学協働プログラム ワークショップ「工学と現代数学の接点を求めて（２)」
  • Place of Presentation: 大阪大学（大阪府・豊中市）
  • Year and Date: 2016-12-20
  • Invited
• [Presentation] Computational modeling of the thrombus formation in the cerebral aneurysm after the endovascular coiling: a Pilot Study (2016)
  • Author(s): T. Otani, S.Ii, T. Shigematsu, T. Fujinaka, T. Ozaki, M. Hirata, S. Wada
  • Organizer: 13th interdisciplinary cerebrovascular symposium international intracranical stent meeting
  • Place of Presentation: 神戸国際会議場（兵庫県・神戸市）
  • Year and Date: 2016-11-26
  • Int'l Joint Research
• [Presentation] A computational approach for blood flow analysis in the densely coiled cerebral aneurysm (2016)
  • Author(s): T. Otani, S.Ii, T. Shigematsu, T. Fujinaka, T. Ozaki, M. Hirata, S. Wada
  • Organizer: IEEE 16th International Conference on Bioinfomatics and Bioengineering
  • Place of Presentation: 台中（台湾）
  • Year and Date: 2016-10-31
  • Int'l Joint Research
• [Presentation] コイル塞栓術後の脳動脈瘤内における血栓形成と血流場の相互作用：計算力学シミュレーションによる検討 (2016)
  • Author(s): 大谷智仁、伊井仁志、和田成生
  • Organizer: 第64回レオロジー討論会
  • Place of Presentation: 大阪大学（大阪府・豊中市）
  • Year and Date: 2016-10-28