Development of Catalytic Reaction Mediated by Early Transition Metal via Sigma-bond Metathesis Reaction
| Project/Area Number |
16H06934
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Nagae Haruki 大阪大学, 基礎工学研究科, 助教 (40779005)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | C-H結合活性化 / 前周期遷移金属 / アミノアルキル化反応 / アミド錯体 / アルキル錯体 / 不斉反応 / 炭素-水素結合活性化 / 炭素―水素結合活性化 |
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| Outline of Final Research Achievements |
The target of this research is development of catalytic C-H bond functionalization mediated by early transition metal complexes which show unique reactivity via σ-bond metathesis reaction. In 2016, I optimized reaction conditions, in which a combination of an trialkylyttrium complex and a bidentate ligand, N,N’-bis(2,6-diisopropylphenyl)ethane-1,2-diamido, showed the highest catalytic activity toward ortho C-H bond aminoalkylation reaction of 2-substituted pyridine derivatives. Based on this result, I am planning to screen chiral bidentate ligands to achieve chiral aminoalkylation reaction.
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Report
(3 results)
Research Products
(15 results)
