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Characteristics of carbapenem-resistant Enterobacteriaceae isolateid in Southeast Asia

Research Project

Project/Area Number 16H06946
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Bacteriology (including mycology)
Research InstitutionOsaka University

Principal Investigator

Sugawara Yo  大阪大学, 微生物病研究所, 特任助教(常勤) (70452464)

Research Collaborator HAGIYA Hideharu  
Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsカルバペネム耐性 / 腸内細菌科細菌 / プラスミド / 薬剤耐性菌 / カルバペネム / 細菌 / 抗生物質 / ゲノム / 感染症
Outline of Final Research Achievements

Spread of carbapenem-resistant Enterobacteriaceae (CRE) has become worldwide concern. In this study, I sought to clarify the characteristics of the CRE strains prevalent in Southeast Asia and their relevance to epidemiology. In Myanmar, two types of plasmids harboring the NDM gene, one of the most prevalent carbepenemase gene worldwide, were prevalent among obtained CRE isolates. They showed different characters in terms of antimicrobial susceptibility and the efficiency of transfer, apparently supporting their differential spread.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Genetic characterization of blaNDM-harboring plasmids in carbapenem-resistant Escherichia coli from Myanmar2017

    • Author(s)
      Sugawara Yo、Akeda Yukihiro、Sakamoto Noriko、Takeuchi Dan、Motooka Daisuke、Nakamura Shota、Hagiya Hideharu、Yamamoto Norihisa、Nishi Isao、Yoshida Hisao、Okada Kazuhisa、Zin Khwar Nyo、Aye Mya Mya、Tomono Kazunori、Hamada Shigeyuki
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 9 Pages: e0184720-e0184720

    • DOI

      10.1371/journal.pone.0184720

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2016-09-02   Modified: 2019-03-29  

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