| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Hair follicle (HF) is a highly organized structure and undergoes hair cycle of anagen-catagen-telogen. Hair cycle is affected by various endocrinological factors including glucocorticoid. The aim of this study is to address the role of local cortisol activation in HF. The expression of 11β-HSD1 was especially strong in CD34 positive HF stem cells and LGR5 positive secondary hair germ. Old age keratinocyte-specific-11β-HSD1 knockout mice (K5-11β-HSD1 KO mice) maintained more hair and the number of hair follicular stem cells was higher compared with wildtype mice. To know the importance of local cortisol activation in keratinocytes, we investigated hair cycle of K5-11β-HSD1 KO mice. After hair plucking, K5-11β-HSD1 KO mice entered anagen earlier than wildtype mice. Keratinocyte- migration was also enhanced in keratinocytes derived from K5-11β-HSD1 KO mice compared with wildtype mice.
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