| Project/Area Number |
16H06954
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
WANG CONG 大阪大学, 医学部附属病院, 医員 (70783893)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | miRNA / RCC / Filamin B / 腎癌 / 腎細胞癌 / マイクロアレイ / RT-PCR / 腎がん / 遺伝子発現 |
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| Outline of Final Research Achievements |
In this study, we could not identified specific miRNA candidate which is correlated with prognosis in renal cell carcinoma(RCC) patients as planed.
But we switched to focus on miRNA which was significantly up-regulated in clear cell renal cell carcinoma (ccRCC) compared to normal tissue by Microarray analysis.Here we showed miR-122 was the most significantly up-reguated miRNA, and by using public prediction tools such as MIRbase, we listed up miR-122 target genes and focusd on the target genes which were correlated with survival in RCC patients by using TCGA data.We identified Filamin B as a target gene of miR-122.Since the fuction of Filamin B in RCC is unknown, we planed to clarify the fuction of miR-122 and Filamin B in RCC.
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