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Study for the interaction between skeletal muscle and the liver on the regulation of metabolic control via the transcription factor KLF15

Research Project

Project/Area Number 16H06970
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionKobe University

Principal Investigator

Okada Yuko  神戸大学, 医学部附属病院, 助教 (90782433)

Co-Investigator(Renkei-kenkyūsha) OGAWA Wataru  神戸大学, 大宇学院医学研究科, 教授 (40294219)
Research Collaborator HIRATA Yu  大学院
Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsエネルギー代謝骨 / 骨格筋 / 糖尿病 / エネルギー代謝
Outline of Final Research Achievements

We have investigated the role of the transcription factor KLF15 in the regulation of systemic metabolism. The abundance of KLF15 in skeletal muscle is upregulated in response to exercise, which is likely mediated via calcium-dependent signaling. The abundance of KLF15 in skeletal muscle is also upregulated in several diabetic model mice and treatment of cultured muscle cells with a high concentration of glucose resulted in the increase in the protein abundance of the transcription factor. Hyperglycemia-induced increase in the protein abundance of KLF15 is attributable to the decrease in the poly-ubiquitination of this protein. Whereas blood glucose levels of muscle-specific KLF15 deficient mice are similar to those of control mice, those of the mutant mice at fasting states are lower, suggesting that KLF15 in skeletal muscle contribute to the regulation of hepatic gluconeogenesis.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (6 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Presentation (5 results)

  • [Int'l Joint Research] New York University Medical Center(米国)

    • Related Report
      2016 Annual Research Report
  • [Presentation] 高血糖はWWP1/KLF15経路を介して筋萎縮を促進する2017

    • Author(s)
      平田悠、野村和弘、千賀陽子、岡田裕子、細岡哲也、小川渉
    • Organizer
      第54回日本臨床分子医学会学術集
    • Place of Presentation
      東京
    • Year and Date
      2017-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高血糖はWWP1/KLF15経路を介して筋萎縮を促進する2017

    • Author(s)
      平田悠、野村和弘、千賀陽子、岡田裕子、細岡哲也、小川渉
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病による筋萎縮の分子機構の解析2017

    • Author(s)
      平田悠、野村和弘、千賀陽子、岡田裕子、細岡哲也、小川渉
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 高血糖はWWP1/KLF15経路を介して筋萎縮を促進する2017

    • Author(s)
      平田悠、野村和弘、千賀陽子、岡田裕子、細岡哲也、小川渉
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病による筋萎縮の分子機構の解析2016

    • Author(s)
      平田悠、野村和弘、千賀陽子、岡田裕子、細岡哲也、小川渉
    • Organizer
      第6回Metabolism Scientific Forum
    • Place of Presentation
      東京
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2022-01-28  

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