Regulation of skin keratinocyte barrier by innate lymphoid cells

Research Project

Project/Area Number	16H06985
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Dermatology
Research Institution	Tottori University
Principal Investigator	SUGITA KAZUNARI 鳥取大学, 医学部附属病院, 講師 (40412647)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	皮膚免疫 / アレルギー / 自然リンパ球 / 免疫学
Outline of Final Research Achievements	Group 2 innate lymphoid cells (ILC2s) are capable of producing Th2 cytokines and play important roles in the initiation of inflammation at epithelial barrier surfaces. The main function of the epithelium is to form a protective barrier against external stimuli. Thus, the role of ILC2s in the epithelium is of great interest to determine the mechanism of allergic diseases, which may pave a way for prevention and new therapeutic approaches. We show here for the first time that ILC2s preferentially target tight junction barrier and promote barrier disruption.