EGFR-TKI resistance and epigenetic alterations in lung cancer treatment

Research Project

Project/Area Number	16H06988
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Respiratory surgery
Research Institution	Okayama University
Principal Investigator	Shien Kazuhiko 岡山大学, 大学病院, 助教 (30708079)
Research Collaborator	SATO Hiroki TOMIDA Shuta TOYOOKA Shinichi
Project Period (FY)	2016-08-26 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	非小細胞肺癌 / EGFR / 薬剤耐性 / マイクロRNA / 癌 / トランスレーショナルリサーチ / 薬剤反応性
Outline of Final Research Achievements	Patients with EGFR-activating mutations who initially respond to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) eventually acquire drug resistance, which is a critical problem in the treatment of patients with advanced lung cancer. In this study, we clarified the relation between epigenetic alteration and EGFR-TKI resistance. We found that the micro RNA-200 and LIN28B axis, known as an oncogenic stem-cell factor, plays an important role in the cell viability of acquired EGFR-TKI resistance cells.

Report

(2 results)

2016 Annual Research Report Final Research Report ( PDF )

Research Products

(2 results)

All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

[Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.2017
- Author(s)
  Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 40847-40847
- DOI
  10.1038/srep40847
- Related Report
  2016 Annual Research Report
- Peer Reviewed / Open Access
[Presentation] Targeting miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2016
- Author(s)
  Kazuhiko Shien, Hiroki Sato, Ken Suzawa, Shuta Tomida, Shinsuke Hashida, Hiromasa Yamamoto, Junichi Soh, Hidejiro Torigoe, Kei Namba, Mototsugu Watanabe, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  IASCL World Congress on Lung Cancer 2016
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Related Report
  2016 Annual Research Report
- Int'l Joint Research