Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
BRONJ (Bisphosphonate[BP]-related oseteonecrosis of the jaw) is intractable disease, and the etiology and treatment are not elucidated yet. Hypothesis; BRONJ is influenced by the abnormality of the immune system. I performed immunocytic analysis of femur, thymus, spleen and peripheral blood and biochemical analysis of the blood serum in normal model mouse and BRONJ model mouse. As a result, various change with the change of T lymphocyte subset such as gamma-delta T cells was observed. This study suggests the possibility that BP treatment brought about the immunosuppression in jawbone.
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