Study of the influences on T lymphocyte subset and stem cells in BRONJ model mice

Research Project

Project/Area Number	16H06993
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Okayama University
Principal Investigator	MATSUI Yuichi 岡山大学, 大学病院, 医員 (50783776)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	歯学 / 顎骨壊死 / 骨代謝 / 免疫学
Outline of Final Research Achievements	BRONJ (Bisphosphonate[BP]-related oseteonecrosis of the jaw) is intractable disease, and the etiology and treatment are not elucidated yet. Hypothesis; BRONJ is influenced by the abnormality of the immune system. I performed immunocytic analysis of femur, thymus, spleen and peripheral blood and biochemical analysis of the blood serum in normal model mouse and BRONJ model mouse. As a result, various change with the change of T lymphocyte subset such as gamma-delta T cells was observed. This study suggests the possibility that BP treatment brought about the immunosuppression in jawbone.

Report

(3 results)