| Project/Area Number |
16H06994
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周病 / 分子標的薬 / ドラッグデリバリーシステム / HighMobilityGroupBox 1 / 分子イメージング / 歯周炎 / HighMobilityGroupBox1 / ナノDDS / 抗炎症作用 / HMGB1 / 歯周病治療薬 / 歯学 / 歯周病治療 / 炎症性疾患 |
|---|
| Outline of Final Research Achievements |
We have suggested that HMGB1 is secreted in response to inflammatory stimuli caused by periodontal infection, which is crucial for the initiation of periodontitis. In this research, we performed basic research for control of periodontal inflammation by HMGB1 neutralizing antibody applied with nano drug delivery system. At first, we confirmed that HMGB1 neutralizing antibody suppress the progression of periodontitis and the liposome holding directivity to inflammatory tissue accumulated at inflammatory periodontal tissue.And I manufactured the liposome holding directivity to inflammatory tissue involving HMGB1 neutralizing antibody. And
Finally, I clarified that the liposome significantly inhibited progression of periodontitis in comparison with the simple substance dosage of HMGB1 neutralizing antibody.
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