Control of periodontal inflammation by anti-inflammatory molecular targeting drug applied with nano drug delivery system
| Project/Area Number |
16H06994
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周病 / 分子標的薬 / ドラッグデリバリーシステム / HighMobilityGroupBox 1 / 分子イメージング / 歯周炎 / HighMobilityGroupBox1 / ナノDDS / 抗炎症作用 / HMGB1 / 歯周病治療薬 / 歯学 / 歯周病治療 / 炎症性疾患 |
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| Outline of Final Research Achievements |
We have suggested that HMGB1 is secreted in response to inflammatory stimuli caused by periodontal infection, which is crucial for the initiation of periodontitis. In this research, we performed basic research for control of periodontal inflammation by HMGB1 neutralizing antibody applied with nano drug delivery system. At first, we confirmed that HMGB1 neutralizing antibody suppress the progression of periodontitis and the liposome holding directivity to inflammatory tissue accumulated at inflammatory periodontal tissue.And I manufactured the liposome holding directivity to inflammatory tissue involving HMGB1 neutralizing antibody. And
Finally, I clarified that the liposome significantly inhibited progression of periodontitis in comparison with the simple substance dosage of HMGB1 neutralizing antibody.
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Report
(3 results)
Research Products
(7 results)
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[Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の 遺伝子発現を促進する2017
Author(s)
青柳浩明, 山城圭介, 井手口英隆, 平田千暁, 河村麻理, ,山崎睦代, 山本直史, 和氣秀徳, 西堀正洋, 高柴正悟
Organizer
日本炎症再生医学会
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