| Project/Area Number |
16H07015
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 上皮間葉転換 / 原発性肝癌 / microRNA / 内胚葉 / EMT |
|---|
| Outline of Final Research Achievements |
The significance of endoderm-related microRNA was investigated in gastrointestinal tumors. Using the the surgically resected specimens (Cholangiocellular carcinoma: n=32, Colorectal cancer: n=72), expressions of miR-1263 and miR-449a were analyzed and correlation to clinicopathological factors was examined. miR-1263 was barely detected and there was no significant difference in the samples. miR-449a was expressed lower in the more malignant colorectal cancer. The patients with lower expression of miR-449a had worse prognosis after surgery. Furthermore, HDAC1 was inversely correlated with miR-449a exression and could be the important target gene of miR-449a. miR-449a might be tumor-suppressor gene for the tumor generated from endodermal organ, especially for colorectal cancer.
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