| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this research, we synthesized a novel surfactant based on poly(2-ethyl-2-oxazoline). The surfactant has a lot of hydrazide groups at water soluble part, therefore, it could undergo cross-link reaction with glutaraldehyde in micelles form. In addition, the surfactant possesses squarain dyes at hydrophobic part. The dyes in micelles core were normally not fluorescent due to H-aggregation but showed turn on fluorescence in reseponse to the collapse of micelles triggered by acid. These features of the micelles would be expected to be useful for theranostics.
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