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Development of animal models for anti-neurofascin 155 antibody-positive inflammatory demyelinating diseases by single chain antibodies

Research Project

Project/Area Number 16H07051
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionKyushu University

Principal Investigator

Hidenori Ogata  九州大学, 大学病院, 助教 (90778838)

Research Collaborator Ito Yuji  鹿児島大学, 理工学研究科, 教授 (60223195)
Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords慢性炎症性脱髄性多発根ニューロパチー / neurofascin 155 / 自己抗体 / フラグメント抗体 / ランビエ絞輪 / neurofascin155 / ファージディスプレイ / 慢性炎症性多発根ニューロパチー
Outline of Final Research Achievements

It has been reported that a subset of chronic inflammatory demyelinating polyneuropathy (CIDP) has autoantibodies against neurofascin 155 (NF155). However, pathogenicity of the antibodies remains to be elucidated. In this study, we aimed to isolate pathogenic single chain variable fragments against NF155 to elucidate pathomechanisms of anti-NF155 antibody-positive CIDP. We constructed an immunoglobulin V-gene phage-display library from the immunoglobulin repertoire of a patient with anti-NF155 antibody-positive CIDP. Then several antigen-specific clones were isolated using a cell panning method.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (8 results)

All 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Anti-neurofascin 155 antibody-related neuropathy2018

    • Author(s)
      Ogata Hidenori、Yamasaki Ryo
    • Journal Title

      Clinical and Experimental Neuroimmunology

      Volume: 9 Issue: 1 Pages: 54-64

    • DOI

      10.1111/cen3.12444

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parallel fluctuation of anti-neurofascin 155 antibody levels with clinico-electrophysiological findings in patients with chronic inflammatory demyelinating polyradiculoneuropathy2018

    • Author(s)
      Fujita Atsushi、Ogata Hidenori、Yamasaki Ryo、Matsushita Takuya、Kira Jun-ichi
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 384 Pages: 107-112

    • DOI

      10.1016/j.jns.2017.11.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ELectron microscopic abnormality and therapeutic efficacy in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin155 immunoglobulin G4 antibody2017

    • Author(s)
      Kuwahara Motoi、Suzuki Hidekazu、Oka Nobuyuki、Ogata Hidenori、Yanagimoto Satoshi、Sadakane Shuji、Fukumoto Yuta、Yamana Masaki、Yuhara Yoshiko、Yoshikawa Keisuke、Morikawa Miyuki、Kawai Shigeru、Okazaki Masahiro、Tsujimoto Toru、Kira Jun-Ichi、Kusunoki Susumu
    • Journal Title

      Muscle Nerve

      Volume: 57 Issue: 3 Pages: 498-502

    • DOI

      10.1002/mus.25757

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies.2017

    • Author(s)
      Koike H, Kadoya M, Kaida KI, Ikeda S, Kawagashira Y, Iijima M, Kato D, Ogata H, Yamasaki R, Matsukawa N, Kira JI, Katsuno M, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry.

      Volume: epub ahead of print Issue: 6 Pages: 465-473

    • DOI

      10.1136/jnnp-2016-314895

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Proposal of diagnostic criteria for anti-neurofascin 155 antibody-associated neuropathy2017

    • Author(s)
      Ogata H, Yamasaki R, Matsushita T, Kadoya M, Kaida K, Matsui M, Kuwabara S, Kusunoki S, Kira JI.
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自己抗体陽性CIDPの臨床像2017

    • Author(s)
      緒方 英紀,山﨑 亮,吉良 潤一
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Clinico-electrophysiological correlation with anti-neurofascin155 antibody levels in the antibody-positive chronic inflammatory demyelinating polyneuropathy2017

    • Author(s)
      Ogata H, Fujita A, Yamasaki R, Matsushita T, Kira JI.
    • Organizer
      2017 PNS Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗neurofascin155抗体関連ニューロパチー暫定診断基準案の策定.2017

    • Author(s)
      79)緒方英紀,山﨑亮,松下拓也,角谷真人,海田賢一,松井真,桑原聡,楠進,吉良潤一
    • Organizer
      第29回日本神経免疫学会学術集会.
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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