| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study investigated the correlation between the degree of synovitis of the hip joint and expression of cytokine or bone metabolism marker in fluid of the hip joint, including TNF-α, IL-6, IL-1β, IL-8, MMP-3, MMP-9, BAP and TRACP5b in patients with osteonecrosis of the femoral head. There were significant correlation between the degree of the synovitis and the expression of IL-8 or TRACP5b, which indicate that synovitis plays an important role on the vascularization or bone resorption in patients with osteonecrosis of the femoral head. Regarding the subchondral insufficiency fracture of the femoral head similar to osteonecrosis of the femoral head, the levels of expression of IL-8, TRACP-5b, VEGF, MMP-9 in cases with progressive collapse were significantly higher than those in cases without progressive collapse, which indicate that increased osteoclast activity may be result of progressive collapse in subchondral insufficiency fracture of the femoral head.
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