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Factors of radioresistance for oral cancer cells which were treated with KPU-300 radiosensitizing therapy.

Research Project

Project/Area Number 16H07076
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionNagasaki University

Principal Investigator

OKUYAMA Kohei  長崎大学, 病院(歯学系), 助教 (30781968)

Research Collaborator SUZUKI Keiji  長崎大学, 原爆後障害医療研究所, 准教授 (00196809)
Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsFucci / 舌癌 / 細胞周期 / 放射線増感 / 微小管重合阻害 / M期 / KPU-300 / Cetuximab / 放射線増感効果 / 歯学 / 細胞・組織 / 癌 / 発生・分化 / 早期舌扁平上皮癌 / 上皮間葉転換 / 未分化部分転化 / E-Cadherin / Cytokeratin-14 / Vimentin / Fucci system / 細胞 / 放射線
Outline of Final Research Achievements

KPU-300 is a novel colchicine-type anti-microtubule agent derived from pulinabulin (NPI-2358). We characterized the effects of KPU-300 on cell cycle kinetics and radiosensitization using SAS cells, oral tongue cancer cell line, expressing the fluorescent ubiquitination-based cell cycle indicator (Fucci). KPU-300 was reported as a potent radiosensitizer which is due to the synchronization of cells in M phase. However, SAS-Fucci cells did not do that; cells tend to be arrested in G1 phase and dead cells were gathered with the center of colony.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (24 results)

All 2018 2017

All Journal Article (8 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (16 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report.2018

    • Author(s)
      Naruse T, Tokuhisa M, Yanamoto S, Sakamoto Y, Okuyama K, Tsuchihashi H, Umeda M.
    • Journal Title

      Oncol lett

      Volume: 15 Pages: 7158-7162

    • DOI

      10.3892/ol.2018.8261

    • NAID

      120006987323

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tooth extraction in a patient after autologous skeletal myoblast sheet transplantation for severe dilated cardiomyopathy2017

    • Author(s)
      Kohei Okuyama, Yuki Sakamoto, Tomofumi Naruse, Souichi Yanamoto, Masahiro Umeda
    • Journal Title

      Annals of Medicine and Surgery

      Volume: 15 Pages: 34-36

    • DOI

      10.1016/j.amsu.2017.01.022

    • NAID

      120006987550

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well-differentiated squamous cell carcinoma: A case report.2017

    • Author(s)
      Okuyama K, Fujita S, Yanamoto S, Naruse T, Sakamoto Y, Kawakita A, Omori K, Tsuchihashi H, Umeda M.
    • Journal Title

      Mol Clin Oncol

      Volume: 7 Issue: 3 Pages: 341-346

    • DOI

      10.3892/mco.2017.1323

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intraoral extraction of an ectopic mandibular third molar detected in the subcondylar region without a pathological cause: a case report and literature review2017

    • Author(s)
      Kohei Okuyama, Yuki Sakamoto, Tomofumi Naruse, Akiko Kawakita, Souichi Yanamoto, Kohei Furukawa, Masahiro Umeda
    • Journal Title

      Cranio.

      Volume: 印刷中 Issue: 5 Pages: 327-331

    • DOI

      10.1080/08869634.2016.1240466

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Therapeutic implication of mTORC2 in oral squamous cell carcinoma.2017

    • Author(s)
      Naruse T, Yanamoto S, Okuyama K, Yamashita K, Omori K, Nakao Y, Yamada SI, Umeda M.
    • Journal Title

      Oral Oncol

      Volume: 65 Pages: 23-32

    • DOI

      10.1016/j.oraloncology.2016.12.012

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential factors influencing the development of oral tongue squamous cell carcinoma in young mature patients: Lingual position of the mandibular second molar and narrow tongue space.2017

    • Author(s)
      Kim Y, Okuyama K, Michi Y, Ohyama Y, Uzawa N, Yamaguchi S.
    • Journal Title

      Oncol lett

      Volume: 14 Pages: 7339-7343

    • DOI

      10.3892/ol.2017.7135

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unusual recurrent tongue spindle cell carcinoma with marked anaplasia following sympatric glossectomy for well-differentiated squamous cell carcinoma2017

    • Author(s)
      Kohei Okuyama, Shuichi Fujita, Souichi Yanamoto, Tomofumi Naruse, Yuki Sakamoto, Akiko Kawakita, Keisuke Omori, Hiroki Tsuchihashi, Masahiro Umeda
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Potential factors influencing the development of oral tongue squamous cell carcinoma in young adult patients: lingual position of the mandibular second molar and narrow tongue space2017

    • Author(s)
      Yusoon Kim, Kohei Okuyama, Yasuyuki Michi, Yoshio Ohyama, Narikazu Uzawa, Satoshi Yamaguchi
    • Journal Title

      Oncology Letters

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 口腔術後創におけるポリグリコール酸シート被覆後に認めた乳頭状肉芽形成に関する臨床的検討.2018

    • Author(s)
      奥山 紘平,柳本 惣市,鳴瀬 智史,六反田 賢,坂本 由紀,大場 誠悟,朝比奈 泉,梅田 正博.
    • Organizer
      第36回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 下顎歯肉扁平上皮癌の骨髄浸潤先端組織におけるCD44v6およびIL-6の発現に関する臨床的・免疫組織化学的解析.2018

    • Author(s)
      福嶋 大将,奥山 紘平,土橋 宏輝,鳴瀬 智史,柳本 惣市,梅田 正博.
    • Organizer
      第36回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 周術期口腔機能管理中に Numb-chin 症候群を発症し、多発性骨髄腫の再燃を早期に発見した1例.2018

    • Author(s)
      古川 浩平,柚鳥 宏和,五月女 さき子,林田 咲,奥山 紘平,鳴瀬 智史,柳本 惣市,川崎 五郎,梅田 正博.
    • Organizer
      第36回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 早期舌扁平上皮癌におけるCancer-associated Fibroblastの発現と腫瘍上皮の未分化部分転化機構に関する解析.2017

    • Author(s)
      奥山 紘平,柳本 惣市,鳴瀬 智史,土橋 宏輝,梅田 正博.
    • Organizer
      第62回日本口腔外科学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔がん化学療法におけるペグフィルグラスチムの使用経験2017

    • Author(s)
      奥山 紘平,柳本 惣市,坂本 由紀,鳴瀬 智史,川北 晃子,大場 誠悟,朝比奈 泉,梅田 正博.
    • Organizer
      第35回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 分類不能型免疫不全症患者に対して観血的歯科治療を施行した1例.2017

    • Author(s)
      奥山 紘平,山口 聰.
    • Organizer
      第26回日本有病者歯科医療学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 早期舌扁平上皮癌の腫瘍浸潤先端部におけるCancer-associated fibroblastsの発現に関する解析.2017

    • Author(s)
      奥山 紘平,柳本 惣市,鳴瀬 智史,土橋 宏輝,品川 兼一,梅田 正博.
    • Organizer
      第71回日本口腔科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Eating function of the cases treated with dental implant after resection of oral cancer.2017

    • Author(s)
      Sakamoto Y, Matsushita Y, Yanamoto S, Okuyama K, Naruse T, Umeda M.
    • Organizer
      5th Congress of Asian Society of Head and Neck Oncology. March 2017, Bali.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic implication of mTORC2 in oral squamous cell carcinoma.2017

    • Author(s)
      Naruse T, Yanamoto S, Okuyama K, Yamashita K, Umeda M.
    • Organizer
      6th World Congress of the International Academy of Oral Oncology, May 2017, Bangalore.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 舌に発生した未分化癌の1例.2017

    • Author(s)
      坂本 由紀,柳本 惣市,奥山 紘平,足立 真基,鳴瀬 智史,梅田 正博.
    • Organizer
      第35回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 早期舌癌頸部後発転移における転移抑制遺伝子NME1の発現に関する免疫組織学的検討.2017

    • Author(s)
      土橋 宏輝,鳴瀬 智史,柳本 惣市,奥山 紘平,山下 健太郎,梅田 正博.
    • Organizer
      第35回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 顎関節強直症を伴ったSAPHO症候群の1例.2017

    • Author(s)
      足立 真基,坂本 由紀,古川 浩平,奥山 紘平,柳本 惣市,梅田 正博.
    • Organizer
      第71回日本口腔科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 舌癌患者における好中球・リンパ球比の予後予測因子としての有用性に関する検討.2017

    • Author(s)
      鳴瀬 智史,柳本 惣市,奥山 紘平,土橋 宏輝,古川 浩平,梅田 正博.
    • Organizer
      第62回日本口腔外科学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 舌癌患者の予後予測における術前末梢血リンパ球数・単球数比の検討.2017

    • Author(s)
      古川 浩平,鳴瀬 智史,土橋 宏輝,奥山 紘平,柳本 惣市,川崎 五郎,梅田 正博.
    • Organizer
      第62回日本口腔外科学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線性顎骨骨髄炎により広範な皮膚壊死を生じた頸部壊死性筋膜炎の1例.2017

    • Author(s)
      土橋 宏輝,鳴瀬 智史,奥山 紘平,赤星 僚一,津田 翔真,古川 浩平,柳本 惣市,梅田 正博.
    • Organizer
      第50回日本口腔科学会九州地方部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 切除困難な下顎歯肉癌頸部リンパ節転移に対しCetuximab併用FP療法中に発症した肺塞栓症の1例.2017

    • Author(s)
      鳴瀬 智史,柳本 惣市,奥山 紘平,土橋 宏輝,津田 翔真,梅田 正博.
    • Organizer
      第21回九州地区口腔癌研究会
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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