| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
The effect of HIV-1 host factors has identified in primary infection. However, the effect in latent infection establishment is unknown. COMMD1 inducible cell line suppressed HIV-1 replication and decreased integrated HIV-1 genome. HIV-1 latently infection establishment and reactivation effect were similar between COMMD1 high and low expressed cells. Moreover, -1kbp COMMD1 promoter construct has highest activity in both myeloid and lymphoid cells. Therefore, this study indicates that COMMD1 doesn’t have effect for HIV-1 latent infection establishment and transcriptional regulation in myeloid cells was regulated in a further upstream.
|
