An establishment of model mice for dominantly inherited growth hormone deficiency and elucidation of its molecular mechanism
| Project/Area Number |
16H07081
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Kumamoto University |
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Principal Investigator |
ARIYASU DAISUKE 熊本大学, 生命資源研究・支援センター, 特定事業研究員 (60338100)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 成長ホルモン / 優性阻害効果 / 小胞体ストレス / 核内転写因子 / 低身長 / 低身長症 / モデルマウス / 成長ホルモン分泌不全性低身長症 / 遺伝学 / ゲノム |
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| Outline of Final Research Achievements |
Abnormllities in the GH1 gene, which codes growth hormone (GH), cause short stature in human. This research focus on inherited GH deficiency, and the researcher established humanized GH mice, namely, endogenous growth hormone genes in mice are exchanged into human GH1 genes in this research. In contrast to well-accepted hypothesis, this disease was turned out to be caused by totally novel mechanism. This is first in vivo study which uncovered a novel mechanism of GH deficiency.
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Report
(3 results)
Research Products
(6 results)
