• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

An establishment of model mice for dominantly inherited growth hormone deficiency and elucidation of its molecular mechanism

Research Project

Project/Area Number 16H07081
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Endocrinology
Research InstitutionKumamoto University

Principal Investigator

ARIYASU DAISUKE  熊本大学, 生命資源研究・支援センター, 特定事業研究員 (60338100)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords成長ホルモン / 優性阻害効果 / 小胞体ストレス / 核内転写因子 / 低身長 / 低身長症 / モデルマウス / 成長ホルモン分泌不全性低身長症 / 遺伝学 / ゲノム
Outline of Final Research Achievements

Abnormllities in the GH1 gene, which codes growth hormone (GH), cause short stature in human. This research focus on inherited GH deficiency, and the researcher established humanized GH mice, namely, endogenous growth hormone genes in mice are exchanged into human GH1 genes in this research. In contrast to well-accepted hypothesis, this disease was turned out to be caused by totally novel mechanism. This is first in vivo study which uncovered a novel mechanism of GH deficiency.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (6 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Endoplasmic Reticulum (ER) Stress and Endocrine Disorders.2017

    • Author(s)
      Ariyasu D, Yoshida H, Hasegawa Y.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Issue: 2 Pages: 382-382

    • DOI

      10.3390/ijms18020382

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] In vivo amalysis using model mice of dominantly inherited GH deficiency2017

    • Author(s)
      有安大典、久保英実香、長谷川奉延、荒木喜美
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 優性遺伝性GH1遺伝子異常症モデルマウスのGH分泌不全は、Ghrhr mRNAの低下による2017

    • Author(s)
      有安大典、久保英実香、長谷川奉延、荒木喜美
    • Organizer
      第51回日本小児内分泌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 優性遺伝性GH1遺伝子異常症の発症機序に関する検討2017

    • Author(s)
      有安大典、久保英実香、長谷川奉延、荒木喜美
    • Organizer
      第30回モロシヌス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 常染色体優性遺伝性GH1遺伝子異常症の発症機序の解明~ヒト化GHマウスを用いたin vivo解析~2016

    • Author(s)
      有安大典
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] 常染色体優性遺伝性GH1遺伝子異常症の発症機序の解明~遺伝子置換システムを用いたヒト化GHマウスの作製~2016

    • Author(s)
      久保英美香
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-09-02   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi