| Project/Area Number |
16H07082
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔がん / がん免疫療法 / 口腔癌 / 腫瘍免疫 / がんペプチドワクチン療法 / がんペプチワクチン療法 / 腫瘍関連抗原 |
|---|
| Outline of Final Research Achievements |
In this study, to develop more effective cancer immunotherapy for oral cancer patients, we attempted to identify several HLA class II-restricted long peptides derived from some tumor antigens. We also tried to develop the biomarkers to predict the therapeutic effects of peptide-based cancer immunotherapy for oral cancer patients.
As a result, we identified several long peptides derived from cancer antigens, such as IMP-3, DEPDC1, and MPHOSPH1. Some of these peptide could activate both helper T cells and cytotoxic T cells, suggesting that these peptides are useful for exhibiting stronger anti-tumor immune responses. In addition, we identified T cells receptors of these tumor antigen-specific helper T cells.
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