| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Glucose promotes membrane fusion between insulin secretory membranes and plasma membranes, and thereby releases insulin from the vesicles in pancreatic beta-cells. Glucose also promotes endocytosis of the fused secretory membranes. Although endocytosis is essential for cell size maintenance before and after insulin secretion and for refilling of insulin granule pools, little is known about the underlying molecular mechanisms. In the present study, I found that Rab27a regulates the complex formation of proton pumps. These results suggest that Rab27a regulates endocytosis via acidification in endocytosed vesicles.
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