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Establishment of removal method of undifferentiated human iPS cells contained in differentiated cells.

Research Project

Project/Area Number 16H07094
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionUniversity of the Ryukyus

Principal Investigator

NAKASHIMA YOSHIKI  琉球大学, 医学(系)研究科(研究院), 助教 (30593082)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords移植・再生医療 / 発生・分化 / 細胞・組織 / バイオリアクター / 再生医学 / シグナル伝達
Outline of Final Research Achievements

Regenerative medicine is expected as a new treatment method that can cure disease that could not be cured so far. Regenerative medicine using iPS cells invented by Professor Shinya Yamanaka in regenerative medicine is expected to be able to treat many diseases of the whole body. However, iPS cells had a risk of developing tumors in the body. The risk can be prevented by removing most of the iPS cells from the therapeutic cells. In this study, we were able to discover drugs that can almost remove iPS cells from therapeutic cells. And it was also found that the drug is not toxic to body cells. By using this research result to the world, it becomes possible to safely perform new treatments using iPS cells.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (2 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Atorvastatin inhibits the HIF1α-PPAR axis, which is essential for maintaining the function of human induced pluripotent stem cells2018

    • Author(s)
      Yoshiki Nakashima1,2,3, Chika Miyagi-Shiohira3, Hirofumi Noguchi3, and Takeshi Omasa1,2
    • Journal Title

      Molecular Therapy (revise)

      Volume: revise

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Patent(Industrial Property Rights)] 分化コントロール化合物を用いて造腫瘍性をもつおそれのある未分化iPS細胞等の混入を除去する方法2018

    • Inventor(s)
      中島義基、大政健史、野口洋文、潮平知佳
    • Industrial Property Rights Holder
      琉球大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-064199
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-12-27  

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