| Project/Area Number |
16H07106
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
Yoneda Masato 横浜市立大学, 附属病院, 講師 (10423831)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯周病 / 生活習慣病 / 非アルコール性脂肪肝炎 / NAFLD / 非アルコール性脂肪性肝炎 / モデルマウス |
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| Outline of Final Research Achievements |
Nonalcoholic steatohepatitis (NASH) is an important cause of chronic liver injury in many countries. The incidence of NAFLD is rising rapidly because of the currently ongoing epidemics of obesity and type 2 diabetes. Bacterial endotoxin, such as lipopolysaccharide (LPS), is known to play a key role in the pathogenesis of NASH. In this project, LPS from p. gingivalis stimulation results in innate immune responses through TLR2 and 4 and elevated ALT in high-fat diet-induced steatosis mice. Furthermore, the STAT3-NFkB are thought to be the important receptor that case liver damage by LPS from p. gingivalis. Clinically, there are significant relation between the incidence of more than 10 lacations of periodontitis (deepest probing depth > 4mm) and the detection frequency of P. gingivalis in NASH patients.
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