Development of anti-PD-1/PD-L1 therapy targeting tumor microenvironment for oral cancer
Project/Area Number |
16H07108
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | Yokohama City University |
Principal Investigator |
OKUBO Makiko 横浜市立大学, 医学研究科, 客員研究員 (10780611)
|
Project Period (FY) |
2016-08-26 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 再発口腔癌 / 放射線照射 / 骨髄由来細胞 / PD-1 / PD-L1 / 口腔癌 / PD-1/PD-L1 / 歯学 |
Outline of Final Research Achievements |
Despite the fact that radiation is one of the standard therapies in patients with oral cancer, tumor can recur even in the early stages of the disease, negatively affecting outcomes and quality of life. Understanding the mechanism of such recurrence is therefore important. In this study, we investigated the tumor microenvironmental changes after radiation using a xenograft mouse model and human OSCC clinical specimens. Local irradiation caused tumor hypoxia and increased infiltration of CD11b+ myeloid cells. They were polarized into CD11b+/F4/80+ macrophages and CD11b+/Gr-1+ myeloid-derived suppressor cells. A few samples showed higher levels of PD-1 and PD-L1 expression in the recurrent tumors than in the untreated primary tumors, but there was no significance. They were small population so that further research will be needed.
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Report
(3 results)
Research Products
(5 results)