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Development of anti-PD-1/PD-L1 therapy targeting tumor microenvironment for oral cancer

Research Project

Project/Area Number 16H07108
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionYokohama City University

Principal Investigator

OKUBO Makiko  横浜市立大学, 医学研究科, 客員研究員 (10780611)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords再発口腔癌 / 放射線照射 / 骨髄由来細胞 / PD-1 / PD-L1 / 口腔癌 / PD-1/PD-L1 / 歯学
Outline of Final Research Achievements

Despite the fact that radiation is one of the standard therapies in patients with oral cancer, tumor can recur even in the early stages of the disease, negatively affecting outcomes and quality of life. Understanding the mechanism of such recurrence is therefore important. In this study, we investigated the tumor microenvironmental changes after radiation using a xenograft mouse model and human OSCC clinical specimens. Local irradiation caused tumor hypoxia and increased infiltration of CD11b+ myeloid cells. They were polarized into CD11b+/F4/80+ macrophages and CD11b+/Gr-1+ myeloid-derived suppressor cells. A few samples showed higher levels of PD-1 and PD-L1 expression in the recurrent tumors than in the untreated primary tumors, but there was no significance. They were small population so that further research will be needed.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation.2016

    • Author(s)
      Okubo M, Kioi M, Nakashima H, Sugiura K, Mitsudo K, Aoki I, Taniguchi H, Tohnai I.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27548-27548

    • DOI

      10.1038/srep27548

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 口腔癌の放射線治療後の再発に関わる骨髄CD11b陽性単球細胞の役割とメカニズムの解明2017

    • Author(s)
      大久保牧子
    • Organizer
      第35回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線照射後の癌微小環境ニッチにおける骨髄細胞の役割2017

    • Author(s)
      大久保牧子
    • Organizer
      第71回日本口腔科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔癌再発に関わる骨髄CD11b陽性単球細胞の役割とバイオマーカーとしての検討2017

    • Author(s)
      大久保牧子
    • Organizer
      第41回日本頭頸部癌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔癌再発を導く骨髄CD11b+単球細胞の分化機構とその役割2016

    • Author(s)
      大久保牧子
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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