| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Despite the fact that radiation is one of the standard therapies in patients with oral cancer, tumor can recur even in the early stages of the disease, negatively affecting outcomes and quality of life. Understanding the mechanism of such recurrence is therefore important. In this study, we investigated the tumor microenvironmental changes after radiation using a xenograft mouse model and human OSCC clinical specimens. Local irradiation caused tumor hypoxia and increased infiltration of CD11b+ myeloid cells. They were polarized into CD11b+/F4/80+ macrophages and CD11b+/Gr-1+ myeloid-derived suppressor cells. A few samples showed higher levels of PD-1 and PD-L1 expression in the recurrent tumors than in the untreated primary tumors, but there was no significance. They were small population so that further research will be needed.
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