Identification and function of circular RNAs in diffuse-type gastric cancer

• Project/Area Number: 16H07123
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Katsutoshi Shoda 京都府立医科大学, 医学部附属病院, 研究員 (70783421)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 環状RNA / びまん性胃癌 / 胃癌 / びまん性 / 遊離RNA / Liquid biopsy / Gastric Cancer

Outline of Final Research Achievements

In recent years, through development of next generation sequencer, it has been confirmed that hundreds of circular RNAs are expressed in humans and function pathophysiologically.
To identify circular RNA that is specifically expressed in diffuse-type gastric cancer, we conducted comprehensive analysis of circular RNA and compared the expression between cancer and noncancerous tissue in patients with diffuse-type gastric cancer. In diffuse stomach cancer, circular RNA in cancer tissues was significantly decreased as compared with noncancerous tissues, suggesting the possibility of functioning as a sponge of cancer related micro RNA.

Research Products

• [Journal Article] Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma. (2018)
  • Author(s): Ogino S, Konishi H, Ichikawa D, Hamada J, Shoda K, Arita T, Komatsu S, Shiozaki A, Okamoto K, Yamazaki S, Yasukawa S, Konishi E, Otsuji E.
  • Journal Title: World J Gastroenterol. Volume: 24 Issue: 8 Pages: 949-956
  • DOI: 10.3748/wjg.v24.i8.949
  • Peer Reviewed / Open Access
• [Journal Article] Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer (2017)
  • Author(s): Kohmoto T, Masuda K, Naruto T, Tange S, Shoda K, Hamada J, Saito M, Ichikawa D, Tajima A, Otsuji E, Imoto I.
  • Journal Title: The Journal of Medical Investigation Volume: 64 Issue: 3.4 Pages: 233-240
  • DOI: 10.2152/jmi.64.233
  • NAID: 130006105184
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Clinical utility of circulating cell-free Epstein-Barr virus DNA in patients with gastric cancer. (2017)
  • Author(s): Shoda K, Ichikawa D, Fujita Y, Masuda K, Hiramoto H, Hamada J, Arita T, Konishi H, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, Imoto I, Otsuji E.
  • Journal Title: Oncotarget. Volume: 8 Pages: 28796-28804
  • NAID: 120006306639
  • Peer Reviewed / Open Access
• [Journal Article] Monitoring the HER2 copy number status in circulating tumor DNA by droplet digital PCR in patients with gastric cancer. (2017)
  • Author(s): Shoda K, Ichikawa D, Fujita Y, Masuda K, Hiramoto H, Hamada J, Arita T, Konishi H, Komatsu S, Shiozaki A, Kakihara N, Okamoto K, Taniguchi H, Imoto I, Otsuji E.
  • Journal Title: Gastric Cancer Volume: 1 Issue: 1 Pages: 126-135
  • DOI: 10.1007/s10120-016-0599-z
  • NAID: 40021062596
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical utility of circulating cell-free Epstein-Barr virus DNA in patients with gastric cancer. (2017)
  • Author(s): Shoda K, Ichikawa D, Fujita Y, Masuda K, Hiramoto H, Hamada J, Arita T, Konishi H, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, Imoto I, Otsuji E.
  • Journal Title: Oncotarget Volume: 17 Issue: 17 Pages: 28796-28804
  • DOI: 10.18632/oncotarget.15675
  • NAID: 120006306639
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Early thrombomodulin-α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery. (2017)
  • Author(s): Konishi H, Okamoto K, Shoda K, Arita T, Kosuga T, Morimura R, Komatsu S, Murayama Y, Shiozaki A, Kuriu Y, Ikoma H, Nakanishi M, Ichikawa D, Fujiwara H, Otsuji E
  • Journal Title: World J Gastroenterol. Volume: 23 Issue: 5 Pages: 891-898
  • DOI: 10.3748/wjg.v23.i5.891
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk Stratification According to the Total Number of Factors That Meet the Indication Criteria for Radical Lymph Node Dissection in Patients with Early Gastric Cancer at Risk for Lymph Node Metastasis (2016)
  • Author(s): Shoda K, Ichikawa D, Arita T, Kosuga T, Konishi H, Morimura R, Murayama Y, Komatsu S, Shiozaki A, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, Okamoto K, Otsuji E
  • Journal Title: Ann Surg Oncol. Volume: Suppl 5 Pages: 792-797
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells (2016)
  • Author(s): Tomohito Arita, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Atsushi Shiozaki, Shinpei Ogino, Yuji Fujita, Hidekazu Hiramoto, Junichi Hamada, Katsutoshi Shoda, Toshiyuki Kosuga, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
  • Journal Title: Oncotarget Volume: 7(35) Issue: 35 Pages: 56855-56863
  • DOI: 10.18632/oncotarget.10869
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant