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The involvement of chemokines in thymic atrophy and its application to forensic practices

Research Project

Project/Area Number 16H07133
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionWakayama Medical University

Principal Investigator

Kawaguchi Takashi  和歌山県立医科大学, 医学部, 準客員研究員 (60781284)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords胸腺萎縮 / 児童虐待 / ストレス / サイトカイン / ケモカイン / 虐待 / 胸腺 / CCR5 / CCR5リガンド / 法医病理学
Outline of Final Research Achievements

We examined the pathophysiological roles of CCR5 in stress-induced thymic atrophy. C57BL/6 (WT) and Ccr5 KO mice were immobilized individually in well-ventilated restrainers for 1 hour daily, and this procedure were repeated the following 2 days. When WT mice were restrained, the thymuses significantly involuted and their weight decreased to 25% of unrestrained thymus weight. However, in Ccr5 KO mice treated with the same manner, the decrease of thymus weight was significantly suppressed. In the next series, restrain stress significantly induced the apoptosis in the thymic cells of WT mice. On the contrary, the absence of CCR5 significantly suppressed apoptosis of thymic cells. These observations implied that the absence of CCR5 resisted stress-induced thymic atrophy. Thus, CCR5-mdiated signals would promote thymic involution induced by restrain stress. From the forensic aspects, CCR5 would be a key molecule for diagnosing abuse in infants and children.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (4 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Suicide by plastic bag suffocation combined with the mixture of citric acid and baking soda in an adolescent2018

    • Author(s)
      Murakami K, Kawaguchi T 他11名
    • Journal Title

      Int J Legal Med

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatal acute intoxication of accidentally ingested nifedipine in an infant - A case report2017

    • Author(s)
      Yamamoto H, Kawaguchi T 他7名
    • Journal Title

      Leg Med (Tokyo)

      Volume: 24 Pages: 12-18

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exaggerated arsenic nephrotoxicity in female mice through estrogen-dependent impairments in the autophagic flux.2016

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Hama M, Kawaguchi T, Sakamoto S, Shinozaki K, Iwahashi Y, Takayasu T, Kondo T.
    • Journal Title

      Toxicology.

      Volume: 339 Pages: 9-18

    • DOI

      10.1016/j.tox.2015.11.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] The involvement of CCR5 in stress-induced thymic atrophy2018

    • Author(s)
      Kondo T, Kawaguchi T 他8名,
    • Organizer
      Annual Meeting of German Society of Legal Medicine
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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