Role of Tenascin X and Decorin in the development of choroidal neovascularization and fibrosis.

Research Project

Project/Area Number	16H07135
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Ophthalmology
Research Institution	Wakayama Medical University
Principal Investigator	IWANISHI HIROKI 和歌山県立医科大学, 医学部, 講師 (40784319)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	滲出型加齢黄斑変性 / 脈絡膜新生血管 / シグナル伝達 / 創傷治癒 / 細胞外マトリックス / 新生血管 / 加齢黄斑変性
Outline of Final Research Achievements	Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness in older people in developed countries. Choroidal neovascularization (CNV) and associated fibrotic tissue formation around CNV are the major features of the exudative form of AMD.It has been reported that extracellular matrix was involved in CNV and fibrotic tissue formation. We investigated the function of tenascin-X and decorin in an in vivo mouse laser induced CNV model. CNV in decorin KO mice was tend to be larger than that of WT mice. There is not significantly difference on the CNV formation between in tenascin-X KO mice and in WT mice.