Research Project
Grant-in-Aid for Research Activity Start-up
This research project developed a combined theoretical and experimental platform for modeling synthetic biomolecular reactions (genetic circuits) in microbe cells using a systems engineering approach. The focus of the project was particularly on the quantitative characterization of the uncertainty of biomolecular reactions that comes from the sparsity of available measurements and stochastic noise in reaction dynamics. We proposed optimization-based parameter identification and design methodologies for model-based development of biomolecular systems. We also developed a microfluidic platform for actuating genetic circuits using dynamic chemical inputs. The developed platform allows for characterization of the frequency response of genetic circuits, which will be helpful to improve mathematical models.
All 2018 2017
All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results, Invited: 1 results)
Journal of The Royal Society Interface
Volume: 15 Issue: 138 Pages: 20170709-20170709
10.1098/rsif.2017.0709
