| Project/Area Number |
16H07181
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
NAITO Hisashi
GOTO Sataro
YOSHIHARA Toshinori
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 運動 / 肥満 / 2型糖尿病 / レドックス制御機構 / 酸化ストレス / 骨格筋 / インスリン抵抗性 / レドックス制御 / キサンチンオキシダーゼ / Nrf2 / 細胞内シグナル伝達 / AMPK / NADPHオキシダーゼ |
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| Outline of Final Research Achievements |
This study aimed to examine the underlying mechanism by which exercise improves insulin resistance from the perspective of redox homeostasis. In lean mice, but not in obese mice, administration of a xanthine oxidase (XO) inhibitor attenuated the activation of intracellular signal transduction and gene expression-related antioxidants following a single bout of exercise. Moreover, the XO inhibitor did not affect increased insulin sensitivity after exercise in obese mice. These results suggest that the effects of reactive oxygen species generation during exercise on intracellular signaling transduction and gene expression in skeletal muscle differ according to insulin resistance status.
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