| Project/Area Number |
16H07182
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
Goto Ayumi 順天堂大学, 医学(系)研究科(研究院), 博士研究員 (20780969)
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| Co-Investigator(Renkei-kenkyūsha) |
NAITO Hisashi 順天堂大学, 大学院スポーツ健康研究科, 教授 (70188861)
KAKIGI Ryo 順天堂大学, 医学部, 助教 (70614931)
YOSHIHARA Toshinori 順天堂大学, COIプロジェクト室, 特任助教 (20722888)
TSUZUKI Takamasa 順天堂大学, スポーツ健康科学部, 助教 (20780068)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨格筋 / 温熱刺激 / サルコペニア / サルコペニア肥満 / 肥満 / 加齢 / JNK / 老齢 / 糖代謝 / 筋萎縮 / 高脂肪食 |
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| Outline of Final Research Achievements |
The purpose of this study was to determine whether in vivo heat treatment can improve an increase in body fat mass, a decrease in muscle mass and glucose tolerance in mice with sarcopenic obesity. According to the results, heat treatment had no effect on body weight, epididymal fat or lower-limb muscle mass in sarcopenic obesity. Fasting blood glucose levels did not change significantly with heat treatment. In contrast, heat treatment resulted in a decreased fasting plasma insulin level. Furthermore, we were able to identify three key enzymes from the glycolytic pathway upregulated by heat treatment, through comprehensive proteomic approaches. Our results indicate that heat treatment improves insulin resistance and the glycolytic pathway in a mice model with sarcopenic obesity. We suggested that heat treatment could be a potential therapeutic treatment for sarcopenic obesity-induced insulin resistance.
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