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Development of novel treatment for rare cancer "Alveolar soft part sarcoma"

Research Project

Project/Area Number 16H07186
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionJuntendo University

Principal Investigator

Mukaihara Kenta  順天堂大学, 医学部, 非常勤助教 (50778991)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords胞巣状軟部肉腫 / チロシンキナーゼ / チロシンキナーゼ阻害剤 / 悪性骨軟部腫瘍 / 希少がん / 分子標的治療
Outline of Final Research Achievements

The aim of this study is developing a novel treatment for alveolar soft part sarcoma, which is a rare malignant tumor. We identified multiple tyrosine kinases, which are related to the mechanism of tumor development. We pre-clinically examined anti-tumor effect against alveolar soft part sarcoma by using tyrosine kinase inhibitor. As a result, Cabozantinib and Dasatinib showed significant anti-tumor activity both in vitro and in vivo. These results indicate that identified tyrosine kinases in this study are promising therapeutic target and these tyrosine kinase inhibitors can be a potent new therapeutic option.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (2 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma2017

    • Author(s)
      Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S,Kobayashi E, Okubo T, Kohsaka S, Saito T, Kaneko K, Suehara Y.
    • Journal Title

      PLoS One

      Volume: 12(9) Issue: 9 Pages: 0185321-0185321

    • DOI

      10.1371/journal.pone.0185321

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 胞巣状軟部肉腫に対するチロシンキナーゼ阻害剤の有効性に関する検討2017

    • Author(s)
      田邊雄、向井原健太
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2017-10-26
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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