| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We found basophil depletion in mouse papain-induced allergic conjunctivitis model induced significant suppression of eosinophil infiltration. We then found that innate lymphoid cell type2 (ILC2) depletion in mouse papain-induced allergic conjunctivitis model induced significant suppression of eosinophil infiltration. Furthermore, we found activation of ILC2 in conjunctival tissue was suppressed in allergic conjunctivitis model using IL-33 (one of the signature cytokines of type 2 immune reaction) knockout mouse. In addition, we found the existence of ILC2 in severe chronic human allergic conjunctivitis tissue (giant papillae tissue obtained from vernal keratoconjunctivitis patients) using flow cytometer (FACS).
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