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Adipose-tissue-derived stem cells could be an ideal cell source for neural regeneration when to treat a fetus in utero

Research Project

Project/Area Number 16H07193
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionShowa University

Principal Investigator

KAWASHIMA AKIHIRO  昭和大学, 医学部, 助教 (10783376)

Project Period (FY) 2016-08-26 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords幹細胞 / 胎児治療 / 先天性代謝疾患 / 脳神経疾患 / 再生医療 / 先天代謝異常症 / 脳機能障害
Outline of Final Research Achievements

Several experimental cell therapies for the fetus has been applied, but there are a few reports to use adipose tissue derived stem cells (ADSCs) as a cell source. The purpose of this study is to define their distribution after in utero ADSC transplantation. ADSCs were isolated from the mouse inguinal adipose tissue by enzymatic digestion. To clarify whether transplanted ADSCs could populate in a brain tissue, ADSCs obtained from CAG-EGFP Tg mice were injected into fetal-brain ventricle at E14.5. ADSCs have a variable appearance having neurite morphology including bulbous cytoplasm with elongated cell process like axon and/or dendrites after neural induction. The cells expressed the neuron-specific markers. The transplanted ADSCs were able to differentiate into neuron-like and astrocyte-like cells. Our data suggest that ADSCs could be a promising cell source of neural regeneration as neural stem cells.

Report

(2 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] Adipose-derived-mesenchymal stem cells could be a promising cell source of tissue regeneration in congenital neural degeneration2017

    • Author(s)
      川嶋章弘
    • Organizer
      第69回日本産科婦人科学会学術講演会
    • Place of Presentation
      広島県立総合体育館
    • Year and Date
      2017-04-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 子宮内胎仔脳室内投与における脂肪組織由来幹細胞の中枢神経系への有効性2016

    • Author(s)
      川嶋章弘
    • Organizer
      第39回分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2018-03-22  

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