Mechanisms of Cdc42 during cartilage development

Research Project

Project/Area Number	16H07199
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Orthodontics/Pediatric dentistry
Research Institution	Showa University
Principal Investigator	NAGAHAMA RYO 昭和大学, 歯学部, 助教 (90783530)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	細胞内シグナル / Cdc42 / 軟骨 / 軟骨成長 / PTH
Outline of Final Research Achievements	To investigate the function of low molecular G protein Cdc42 on chondrogenesis during the postnatal growth phase, Cdc42 conditional knockout mice (Cdc42 cKO) in which Cdc42 is specifically deleted by tamoxifen administration was prepared. The body length and body weight of Cdc42 cKO mice were lower than those of control mice. Abnormal cartilage tissues were observed in long bone growth plates of Cdc42 cKO mice. These results suggest that Cdc42 plays an important role in cartilage formation during postnatal growth period.